Treatment of elderly cancer patients with chemotherapy Journal Article
| Authors: | Wasil, T.; Lichtman, S. M. |
| Article Title: | Treatment of elderly cancer patients with chemotherapy |
| Abstract: | Persons over the age of 65 are the fastest growing segment of the United States population. In the next 30 years, they will comprise over 20 percent of the population. Fifty percent of all cancers occur in this age group and, therefore, there will be an expected rise in the total cancer burden. Data is becoming available that will better guide the use of chemotherapy in the older patient population. Information regarding age-related physiologic changes are presented with their relationship to pharmacology, functional status, and hematopoiesis. Treatments are reviewed in regard to the adjuvant treatment of breast and colon cancer as well as primary therapy of aggressive non-Hodgkin's lymphoma. The treatment of more advanced breast, ovary and non-small cell lung cancer also are discussed. Copyright © Taylor & Francis Inc. |
| Keywords: | cancer chemotherapy; cancer survival; treatment outcome; aged; cancer surgery; functional assessment; prednisone; drug tolerability; neutropenia; review; cancer recurrence; bevacizumab; cisplatin; doxorubicin; fluorouracil; diarrhea; drug efficacy; drug safety; hypertension; multimodality cancer therapy; antineoplastic agents; capecitabine; gemcitabine; paclitaxel; cancer adjuvant therapy; cancer radiotherapy; chemotherapy; methotrexate; rituximab; antineoplastic agent; endometrium cancer; neoplasms; colorectal cancer; carboplatin; unindexed drug; metastasis; ovary cancer; breast cancer; anemia; bone marrow suppression; bleeding; lung non small cell cancer; lung resection; mucosa inflammation; nausea; vomiting; peripheral neuropathy; aromatase inhibitor; cyclophosphamide; vincristine; kidney failure; patient monitoring; enzyme activity; cetuximab; high risk patient; docetaxel; irinotecan; monoclonal antibody; drug hypersensitivity; rash; chemotherapy induced emesis; gastrointestinal toxicity; nonhodgkin lymphoma; kidney function; randomized controlled trials; folinic acid; cardiotoxicity; partial mastectomy; comorbidity; gefitinib; tamoxifen; glomerulus filtration rate; hematopoiesis; aging; platinum derivative; osteoporosis; drug metabolism; taxane derivative; trastuzumab; anastrozole; oxaliplatin; wound healing impairment; geriatric patient; proteinuria; hearing impairment; amifostine; creatinine clearance; serotonin 3 antagonist; elderly patients; age-related physiology |
| Journal Title: | Cancer Investigation |
| Volume: | 23 |
| Issue: | 6 |
| ISSN: | 0735-7907 |
| Publisher: | Informa Healthcare |
| Date Published: | 2005-01-01 |
| Start Page: | 537 |
| End Page: | 547 |
| Language: | English |
| DOI: | 10.1080/07357900500202770 |
| PUBMED: | 16203662 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 7" - "Export Date: 24 October 2012" - "CODEN: CINVD" - "Source: Scopus" |
