Model for intermediate steps in monocytic differentiation: c-myc, c-fms, and ferritin as markers Journal Article
| Authors: | Cayre, Y.; Raynal, M. C.; Darzynkiewicz, Z.; Dorner, M. H. |
| Article Title: | Model for intermediate steps in monocytic differentiation: c-myc, c-fms, and ferritin as markers |
| Abstract: | A mature hematopoietic cell represents the end product of a stepwise differentiation process. As a model system for studying differentiation, the human promyelocytic leukemia cell line HL-60 undergoes terminal monocytic/macrophagic differentiation following exposure to either phorbol 12-myristate 13-acetate or 1,25-dihydroxyvitamin D3. We have derived and analyzed a variant HL-60 cell line, 1F10, that permits the study of several intermediate steps in the myeloid differentiation process. These intermediate steps are documented by cell cycle data and phenotype analysis as well as markers such as c-myc, c-fms, and both subunits of ferritin. |
| Keywords: | acute granulocytic leukemia; genetics; flow cytometry; cytology; proto oncogene; biological model; models, biological; cell line; genetic variability; genetic transcription; cell differentiation; transcription, genetic; monoclonal antibody; fluorescent antibody technique; antibodies, monoclonal; messenger rna; rna, messenger; monocyte; monocytes; ferritin; ferritins; proto-oncogenes; variation (genetics); leukemia, myelocytic, acute; humans; human; article |
| Journal Title: | Proceedings of the National Academy of Sciences of the United States of America |
| Volume: | 84 |
| Issue: | 21 |
| ISSN: | 0027-8424 |
| Publisher: | National Academy of Sciences |
| Date Published: | 1987-11-01 |
| Start Page: | 7619 |
| End Page: | 7623 |
| Language: | English |
| DOI: | 10.1073/pnas.84.21.7619 |
| PUBMED: | 3313399 |
| PROVIDER: | scopus |
| PMCID: | PMC299351 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 5 February 2021 -- Source: Scopus |
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