| Abstract: |
To the Editor: In Part I of their review on congenital adrenal hyperplasia (June 11 issue),1 White et al. discuss the steroidogenic enzymes and the clinical manifestations of disorders involving those enzymes; another detailed review has recently been published.2 The discussion by White et al. of the molecular genetics of 21-hydroxylase deficiency in Part II of their review (June 18 issue)3 is a bit more controversial. Their studies and those of most other groups have been similar: genomic DNA from patients with congenital adrenal hyperplasia was digested with the restriction endonuclease TaqI and analyzed by probing Southern blots with... © 1987, Massachusetts Medical Society. All rights reserved. |
