Congenital adrenal hyperplasia (First of two parts) Journal Article
| Authors: | White, P. C.; New, M. I.; Dupont, B. |
| Article Title: | Congenital adrenal hyperplasia (First of two parts) |
| Abstract: | (First of Two Parts) CONGENITAL adrenal hyperplasia results from an inherited defect in any of the five enzymatic steps required to synthesize Cortisol from cholesterol. A defect in a particular step may be manifested clinically, not only because cortisol and other steroid hormones are not synthesized effectively but also because precursor steroids proximal to the blocked step may accumulate and be shunted into other metabolic pathways, particularly that of androgen biosynthesis. For example, in one of the earliest reports (in 1865) of a case of congenital adrenal hyperplasia, de Crecchio described a person who was considered to be a female... © 1987, Massachusetts Medical Society. All rights reserved. |
| Keywords: | review; diagnosis; endocrine system; etiology; human; priority journal; support, non-u.s. gov't; support, u.s. gov't, p.h.s.; congenital adrenal hyperplasia; congenital disorder; adrenal hyperplasia, congenital; hydroxyprogesterone |
| Journal Title: | New England Journal of Medicine |
| Volume: | 316 |
| Issue: | 24 |
| ISSN: | 0028-4793 |
| Publisher: | Massachusetts Medical Society |
| Date Published: | 1987-06-11 |
| Start Page: | 1519 |
| End Page: | 1524 |
| Language: | English |
| DOI: | 10.1056/nejm198706113162406 |
| PUBMED: | 3295543 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Review -- Export Date: 5 February 2021 -- Source: Scopus |
