Response of human-immunodeficiency-virus-associated neurological disease to 3'-azido-3'-deoxythymidine Journal Article
| Authors: | Yarchoan, R.; Brouwers, P.; Spitzer, A. R.; Grafman, J.; Safai, B.; Perno, C. F.; Larson, S. M.; Berg, G.; Fischl, M. A.; Wichman, A.; Thomas, R. V.; Brunetti, A.; Schmidt, P. J.; Myers, C. E.; Broder, S. |
| Article Title: | Response of human-immunodeficiency-virus-associated neurological disease to 3'-azido-3'-deoxythymidine |
| Abstract: | Four patients with human-immunodeficiency-virus-associated neurological disease were treated with 3'-azido-3'-deoxythymidine (AZT). Three (two with chronic dementia, and one with chronic dementia and peripheral neuropathy) improved as assessed by clinical examination, psychometric tests, nerve conduction studies, and/or positron emission tomography; there was no improvement in the fourth patient who presented with paraplegia. These results support the hypothesis that certain AIDS-virus-associated neurological abnormalities are reversible by antiretroviral chemotherapy. © 1987. |
| Keywords: | adult; middle aged; case report; drug efficacy; peripheral neuropathy; central nervous system; diagnosis; dementia; brain disease; brain diseases; drug derivative; antivirus agent; acquired immune deficiency syndrome; acquired immunodeficiency syndrome; drug therapy; neurologic disease; therapy; thymidine; peripheral nervous system; human immunodeficiency virus 1; zidovudine; nervous system; nervous system diseases; paraplegia; humans; human; male; priority journal; article; analogs and derivatives |
| Journal Title: | Lancet |
| Volume: | 329 |
| Issue: | 8525 |
| ISSN: | 0140-6736 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 1987-01-17 |
| Start Page: | 132 |
| End Page: | 135 |
| Language: | English |
| DOI: | 10.1016/s0140-6736(87)91968-4 |
| PUBMED: | 2879972 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 5 February 2021 -- Source: Scopus |
