Pituitary and testicular hormonal function after treatment for germ cell tumours Journal Article

  


Authors: Bosl, G. J.; Bajorunas, D.
Article Title: Pituitary and testicular hormonal function after treatment for germ cell tumours
Abstract: The endocrine effects of cisplatin based chemotherapy in patients with germ cell tumours were studied in twenty-two patients 9+ to 24+ months after completing treatment. The mean basal FSH and stimulated LH and FSH levels were found to be elevated in treated patients when compared to untreated controls. Serum testosterone levels in treated patients were similar to those in untreated controls. Mean basal LH and FSH levels tended to return toward normal in those patients treated more than 18 months prior to study, and were lower in patients less than 25 years of age at the time of treatment when compared to those aged over 25. These data demonstrate that compensated hypogonadism is common after treatment for metastatic germ cell tumours that young patients appear to be more resistant to the effects of cisplatin based chemotherapy, and that these effects tend to recover with time.
Keywords: clinical article; cisplatin; cancer combination chemotherapy; etoposide; cyclophosphamide; vinblastine; age; dactinomycin; bleomycin; testosterone blood level; hypogonadism; drug therapy; adverse drug reaction; therapy; intravenous drug administration; reproductive toxicity; endocrine system; intoxication; follitropin blood level; luteinizing hormone blood level; male genital system; human; priority journal
Journal Title: International Journal of Andrology
Volume: 10
Issue: 1
ISSN: 0105-6263
Publisher: Wiley Blackwell  
Date Published: 1987-02-01
Start Page: 381
End Page: 384
Language: English
DOI: 10.1111/j.1365-2605.1987.tb00206.x
PUBMED: 2438229
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0023213827&doi=10.1111%2fj.1365-2605.1987.tb00206.x&partnerID=40&md5=3e67d293ae6f10a6259d9448e58301dc
Notes: Article -- Export Date: 5 February 2021 -- Source: Scopus
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MSK Authors
  1. George Bosl
    430 Bosl
  2. Daiva R. Bajorunas
    24 Bajorunas
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