Impaired testicular function after an ifosfamide-containing regimen for pediatric osteosarcoma: A case series and review of the literature Journal Article
| Authors: | Kenney, L. B.; Duffey-Lind, E.; Ebb, D.; Sklar, C. A.; Grier, H.; Diller, L. |
| Article Title: | Impaired testicular function after an ifosfamide-containing regimen for pediatric osteosarcoma: A case series and review of the literature |
| Abstract: | To assess testicular function after standard dose ifosfamide, we evaluated 6 young adult osteosarcoma survivors (median age at diagnosis, 16.5 y; median follow-up, 4 y) treated with ifosfamide (median dose, 45.5 g/m) as part of a chemotherapy regimen (adriamycin/cisplatin/methotrexate/ifosfamide/ ±muramyl-tripeptide-phosphatidyl-ethanolamine). Four of 6 survivors (67%) had abnormal semen analysis (2 oligospermic, 2 azoospermic). Of those, 1/4 had reduced testicular volume, and 2/3 elevated FSH levels. All reported adequate sexual function, 6/6 had normal testosterone levels, but 4/6 had elevated LH levels. Ifosfamide exposure in the context of this regimen was associated with a high likelihood of impaired spermatogenesis and Leydig cell insufficiency. © 2014 by Lippincott Williams & Wilkins. |
| Keywords: | osteosarcoma; ifosfamide; infertility; cancer survivor; leydig cell dysfunction |
| Journal Title: | Journal of Pediatric Hematology/Oncology |
| Volume: | 36 |
| Issue: | 3 |
| ISSN: | 1077-4114 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 2014-04-01 |
| Start Page: | 237 |
| End Page: | 240 |
| Language: | English |
| DOI: | 10.1097/MPH.0b013e3182a27c39 |
| PROVIDER: | scopus |
| PUBMED: | 24667129 |
| DOI/URL: | |
| Notes: | Export Date: 1 May 2014 -- CODEN: JPHOF -- Source: Scopus |
