Ifosfamide plus high-dose cisplatin in patients with non-small cell lung cancer previously treated with chemotherapy Journal Article
| Authors: | Miller, V. A.; Rigas, J. R.; Pisters, K. M. W.; Pfister, D. G.; Heelan, R. T.; Kris, M. G. |
| Article Title: | Ifosfamide plus high-dose cisplatin in patients with non-small cell lung cancer previously treated with chemotherapy |
| Abstract: | This study determined the maximum tolerated dose (MTD) of ifosfamide that could be given with high-dose cisplatin to non-small cell lung cancer (NSCLC) patients previously treated with non-platin-containing chemotherapy and to assess the efficacy of this combination. Twenty-three patients with inoperable NSCLC treated with one prior chemotherapy regimen received continuous infusion ifosfamide 1.2 g/m2 per day with MESNA for 5 days every 35 days and cisplatin 120 mg/m2. After one patient who received cisplatin as a single dose developed grade 4 nephrotoxicity and myelosuppression, cisplatin was given in four divided doses (30 mg/m2 per day) and the ifosfamide dose was lowered to 1.0 g/m2 per day, infused over 4 days. Dose- limiting grades 3 and 4 leukopenia was seen in 43%. A major objective response rate of 9% was observed. The 1-year survival was 30%, with a median survival of 6.4 months. The MTD of ifosfamide administered with cisplatin (30 mg/m2 per day for 4 consecutive days) to this population of patients is 1.0 g/m2 daily for 4 days. This combination produced limited anticancer activity and significant toxicity. Excessive toxicity was observed when cisplatin was given as a single dose with ifosfamide, and this schedule should not be used. |
| Keywords: | adult; cancer survival; controlled study; major clinical study; clinical trial; cisplatin; cancer combination chemotherapy; dose response; treatment planning; drug megadose; cancer grading; controlled clinical trial; phase 2 clinical trial; lung non small cell cancer; antineoplastic activity; continuous infusion; ifosfamide; patient compliance; phase 1 clinical trial; non-small cell lung cancer; human; male; female; article |
| Journal Title: | American Journal of Clinical Oncology |
| Volume: | 18 |
| Issue: | 4 |
| ISSN: | 0277-3732 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 1995-08-01 |
| Start Page: | 303 |
| End Page: | 306 |
| Language: | English |
| DOI: | 10.1097/00000421-199508000-00007 |
| PUBMED: | 7625371 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 28 August 2018 -- Source: Scopus |
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