Altered renin and aldosterone excretion in patients treated for metastatic germ cell tumours Journal Article
| Authors: | Bosl, G. J.; Leitner, S. P.; Atlas, S. A.; Sealey, J. E.; Preibisz, J. J.; Scheiner, E. |
| Article Title: | Altered renin and aldosterone excretion in patients treated for metastatic germ cell tumours |
| Abstract: | Twenty-four patients with metastatic germ cell tumours were studied for abnormalities in the renin-aldosterone axis and for persistent abnormalities of renal function 9+ to 54+ months following completion of cisplatin based chemotherapy. Increased plasma renin activity and aldosterone were identified in fourteen of nineteen (79%) patients. The mean serum magnesium was subnormal. Statistically lower serum phosphorus levels, and higher urea and creatinine levels were also observed. No patient was hypertensive or on diuretics at the time of study. Since vascular toxicity has been reported after cisplatin based chemotherapy and hypomagnesaemia and increased plasma renin activity have been linked to cardiovascular events, these data imply that germ cell tumour patients treated with cisplatin based chemotherapy should be carefully observed for delayed cardiovascular toxicity. |
| Keywords: | clinical article; cisplatin; cancer combination chemotherapy; nephrotoxicity; etoposide; cyclophosphamide; vinblastine; kidney; cardiotoxicity; cardiovascular system; dactinomycin; bleomycin; drug therapy; adverse drug reaction; therapy; intravenous drug administration; intoxication; male genital system; magnesium blood level; human; priority journal; plasma renin activity; aldosterone blood level |
| Journal Title: | International Journal of Andrology |
| Volume: | 10 |
| Issue: | 1 |
| ISSN: | 0105-6263 |
| Publisher: | Wiley Blackwell |
| Date Published: | 1987-02-01 |
| Start Page: | 353 |
| End Page: | 357 |
| Language: | English |
| DOI: | 10.1111/j.1365-2605.1987.tb00202.x |
| PUBMED: | 2438226 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 5 February 2021 -- Source: Scopus |
