Comparison of cytologic and genetic distances between long arm subtelomeric markers of human autosome 14 suggests uneven distribution of crossing-over Journal Article
| Authors: | Purrello, M.; Alhadeff, B.; Whittington, E.; Buckton, K. E.; Daniel, A.; Arnaud, P.; Rocchi, M.; Archidiacono, N.; Filippi, G.; Siniscalco, M. |
| Article Title: | Comparison of cytologic and genetic distances between long arm subtelomeric markers of human autosome 14 suggests uneven distribution of crossing-over |
| Abstract: | The analysis of two rodent × human somatic cell hybrids, carrying different inborn translocations of the human chromosome 14 long arm, has permitted us to narrow down the localization of the structural locus for alpha-1-antitrypsin (PI) to band 14q32.1, proximally to the highly polymorphic DNA locus D14S1 which has been localized by previous studies between 14q32.1 and 14q32.2. These data, evaluated in conjunction with other published information, suggest that the DI4SI locus is cytologically equidistant from both the PI locus and the complex locus for the immunoglobulin heavy chains (IGH) but, genetically, it appears much closer to the latter since the recombination frequency reported between the IGH complex and PI is six times greater than that between the IGH complex and D14SI (lod score peaks respectively at 26% and 4% with narrow fiducial limits). The present report adds further strength to the frequently proposed hypothesis of a nonlinear relationship between cytologic and genetic distances of human genes. The possibility that this phenomenon may be a feature of frequent occurrence throughout the entire human genome is discussed. © 1987 S. Karger AG, Basel. |
| Keywords: | human cell; animals; mice; heredity; histology; pedigree; gene mapping; immunoglobulin heavy chain; genetic recombination; genetic engineering; rodentia; radioisotope; karyotyping; linkage (genetics); genetic linkage; genetic markers; alpha 1 antitrypsin; crossing over; crossing over, genetic; hybrid cell; hybrid cells; chromosome banding; chromosomes, human, pair 14; normal value; chromosome 14; humans; human; male; female; genetic distance; blood and hemopoietic system |
| Journal Title: | Cytogenetics and Cell Genetics |
| Volume: | 44 |
| Issue: | 1 |
| ISSN: | 0301-0171 |
| Publisher: | S. Karger AG |
| Date Published: | 1987-01-01 |
| Start Page: | 32 |
| End Page: | 40 |
| Language: | English |
| DOI: | 10.1159/000132337 |
| PUBMED: | 3469062 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 5 February 2021 -- Source: Scopus |
