Deregulation of MUM1/IRF4 by chromosomal translocation in multiple myeloma Journal Article


Authors: Iida, S.; Rao, P. H.; Butler, M.; Corradini, P.; Boccadoro, M.; Klein, B.; Chaganti, R. S. K.; Dalla-Favera, R.
Article Title: Deregulation of MUM1/IRF4 by chromosomal translocation in multiple myeloma
Abstract: The pathogenesis of multiple myeloma (MM), an incurable a tumour causing the deregulated proliferation of terminally differentiated B cells, is unknown1. Chromosomal translocations (14q1) affecting band 14q32 and unidentified partner chromosomes are common in this tumour, suggesting that they may cause the activation of novel oncogenes2, 3. By cloning the chromosomal breakpoints in an MM cell line, we show that the 14q+ translocation represents a t(6;14)(p25;q32) and that this aberration is recurrent in MM, as it was found in two of eleven MM cell lines. The translocation juxtaposes the immunoglobulin heavy-chain (IgH) locus to MUM1 (multiple myeloma oncogene 1)IRF4 gene, a member of the interferon regulatory factor (IRF) family known to be active in the control of B-cell proliferation and differentiation. As a result, the MUM1/IRF4 gene is overexpressed-an event that may contribute to tumorigenesis, as MUM1/IRF4 has oncogenic activity in vitro. These findings identify a novel genetic alteration associated with MM, with implications for the pathogenesis and diagnostics of this tumour. © 1997 Nature Publishing Group.
Journal Title: Nature Genetics
Volume: 17
Issue: 2
ISSN: 1061-4036
Publisher: Nature Publishing Group  
Date Published: 1997-10-01
Start Page: 226
End Page: 230
Language: English
DOI: 10.1038/ng1097-226
PROVIDER: scopus
PUBMED: 9326949
DOI/URL:
Notes: Letter -- Export Date: 17 March 2017 -- Source: Scopus
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  1. Pulivarth H Rao
    66 Rao
  2. Raju S K Chaganti
    391 Chaganti