Novel identification of t(14;18)(q32;q21)/IGH::MALT1 in chronic lymphocytic leukaemia Journal Article
| Authors: | Kumar, J.; Ewalt, M. D.; Zhang, Y.; Yao, J.; Thompson, M. C.; Dogan, A. |
| Article Title: | Novel identification of t(14;18)(q32;q21)/IGH::MALT1 in chronic lymphocytic leukaemia |
| Abstract: | Chronic lymphocytic leukaemia (CLL) is a clonal B-cell malignancy and remains a chronic disease despite improvements in clinical outcomes since the use of targeted therapies. Both clinical and biological parameters are important for determining prognosis. Unlike other mature B-cell lymphomas, translocations involving the immunoglobulin heavy chain (IGH) locus are uncommon in CLL. There have been few case reports of CLL harbouring t(14;18)/IGH::BCL2 and t(14;19)/IGH::BCL3. Here we describe the first two cases of patients with CLL with documented t(14;18)(q32;q21)/IGH::MALT1. Both cases in this report were associated with lower-risk biological parameters. Thus, FISH testing for MALT1 in cases with unknown IGH translocation partners in the setting of CLL should be implemented in clinical practice to better define such cases. © 2023 British Society for Haematology and John Wiley & Sons Ltd. |
| Keywords: | adult; clinical article; human tissue; middle aged; gene translocation; human cell; single nucleotide polymorphism; disease course; neutropenia; case report; follow up; clinical practice; computer assisted tomography; anemia; thrombocytopenia; genetic variability; gene frequency; pathology; caspase; caspases; fluorescence in situ hybridization; immunoglobulin heavy chain; laboratory test; gene identification; translocation, genetic; chronic lymphatic leukemia; leukocytosis; marginal zone lymphoma; lymphadenopathy; leukemia, lymphocytic, chronic, b-cell; cll; cervical lymphadenopathy; lymphoma, b-cell, marginal zone; first-line treatment; body weight loss; chromosomes, human, pair 14; chromosome 14; neck swelling; high throughput sequencing; humans; prognosis; human; male; article; mucosa associated lymphoid tissue lymphoma translocation protein 1; t(14; obinutuzumab; loss of appetite; venetoclax; 18); chronic lymphocytic leukaemia; igh::malt1; mucosa-associated lymphoid tissue lymphoma translocation 1 protein; malt1 protein, human; axillary lymphadenopathy; igh gene; malt1 gene; pelvis lymphadenopathy |
| Journal Title: | British Journal of Haematology |
| Volume: | 204 |
| Issue: | 2 |
| ISSN: | 0007-1048 |
| Publisher: | John Wiley & Sons |
| Date Published: | 2024-02-01 |
| Start Page: | 561 |
| End Page: | 565 |
| Language: | English |
| DOI: | 10.1111/bjh.19235 |
| PUBMED: | 38031233 |
| PROVIDER: | scopus |
| PMCID: | PMC10922630 |
| DOI/URL: | |
| Notes: | The MSK Cancer Center Support Grant (P30 CA008748) is acknowledged in the PDF -- Corresponding author is MSK authors: Jyoti Kumar -- Source: Scopus |
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