Reduced cerebral glucose metabolism and increased brain capillary permeability following high‐dose methotrexate chemotherapy: A positron emission tomographic study Journal Article

  

Authors:	Phillips, P. C.; Dhawan, V.; Strother, S. C.; Sidtis, J. J.; Evans, A. C.; Allen, J. C.; Rottenberg, D. A.
Article Title:	Reduced cerebral glucose metabolism and increased brain capillary permeability following high‐dose methotrexate chemotherapy: A positron emission tomographic study
Abstract:	Regional glucose metabolic rate constants and blood‐to‐brain transport of rubidium were estimated using positron emission tomography in an adolescent patient with a brain tumor, before and after chemotherapy with intravenous high‐dose methotrexate. Widespread depression of cerebral glucose metabolism was apparent 24 hours after drug administration, which may reflect reduced glucose phosphorylation, and the influx rate constant for 82Rb was increased, indicating a drug‐induced alteration in blood–brain barrier function. Associated changes in neuropsychological performance, electroencephalogram, and plasma amino acid concentration were identified in the absence of evidence of systemic methotrexate toxicity, suggesting primary methotrexate neurotoxicity. Copyright © 1987 American Neurological Association
Keywords:	adolescent; cancer chemotherapy; case report; methotrexate; neurotoxicity; positron emission tomography; brain tumor; computer assisted tomography; central nervous system; brain; diagnosis; medulloblastoma; blood brain barrier; blood-brain barrier; fluorodeoxyglucose f 18; brain diseases; glucose; drug dose; drug therapy; radioisotopes; adverse drug reaction; therapy; intravenous drug administration; acute disease; tomography, emission-computed; nervous system; computer analysis; intoxication; brain metabolism; rubidium 82; capillary permeability; rubidium; humans; human; male; priority journal; glucose brain level; blood and hemopoietic system; glucose phosphorylation; peripheral vascular system
Journal Title:	Annals of Neurology
Volume:	21
Issue:	1
ISSN:	0364-5134
Publisher:	Wiley Blackwell
Date Published:	1987-01-01
Start Page:	59
End Page:	63
Language:	English
DOI:	10.1002/ana.410210111
PUBMED:	3493728
PROVIDER:	scopus
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-0023148098&doi=10.1002%2fana.410210111&partnerID=40&md5=8727f2825e67b6323b362a4aaabbb800
Notes:	Article -- Export Date: 5 February 2021 -- Source: Scopus; Acknowledgements: The authors wish to thank Anastasia Gari and Maria Sergi for aid in data gathering and analysis and Adele Ahronheim for manuscript preparation

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