Imaging surrogates of tumor response to therapy: Anatomic and functional biomarkers Journal Article
| Authors: | Zhao, B.; Schwartz, L. H.; Larson, S. M. |
| Article Title: | Imaging surrogates of tumor response to therapy: Anatomic and functional biomarkers |
| Abstract: | This article addresses the current status of quantitative imaging as a surrogate biomarker for the assessment of tumor response to therapy with non-small cell lung cancer as an example. In addition, the article discusses the limitations of conventional response criteria in the new era of molecular-targeted agents for cancer treatment; the increasing need for more accurate and early response-assessment methods, particularly for volumetric CT; new tumor-specific radiotracers and molecular imaging technologies; and the future applications of molecular imaging with PET for studying various features of cancer metabolism, endocrine status, hypoxia, and oncofetal and differentiation antigens. COPYRIGHT © 2009 by the Society of Nuclear Medicine, Inc. |
| Keywords: | cancer chemotherapy; treatment response; cancer surgery; unclassified drug; clinical feature; erlotinib; monotherapy; disease marker; cancer radiotherapy; gadolinium; positron emission tomography; radiopharmaceuticals; neoplasms; biological marker; animals; gastrointestinal stromal tumor; imatinib; tumor volume; lung non small cell cancer; carcinoma, non-small-cell lung; lung neoplasms; clinical assessment; tumor markers, biological; lung cancer; tomography, x-ray computed; molecular imaging; diagnostic imaging; cancer therapy; cancer mortality; hypoxia; drug uptake; fluorodeoxyglucose f 18; fluorodeoxyglucose f18; positron-emission tomography; gefitinib; radiopharmaceutical agent; lung alveolus cell carcinoma; 1 fluoro 3 (2 nitro 1 imidazolyl) 2 propanol f 18; iodine 124; tracer; drug half life; trastuzumab; 3' fluorothymidine f 18; acetic acid c 11; copper 64; gallium 68; cone beam computed tomography; methionine c 11; differentiation antigen; oncofetal antigen; functional/molecular imaging; response assessment; surrogate biomarker; volumetric ct; 16 alpha fluoro 17 beta estradiol f 18; 16 beta fluoro 5 alpha dihydrotestosterone f 18; chimeric antibody g250 i 124; fluorocyclobutylcarboxylic acid f 18; fluoroethanylarabinosyluridine f 18; fluoroiodoarabinosylurideine i 124; monoclonal antibody 3f8 i 124; monoclonal antibody a33 i 124; sodium i 124; trastuzumab cu 64; trastuzumab ga 68; endocrine system; fluorine radioisotopes |
| Journal Title: | Journal of Nuclear Medicine |
| Volume: | 50 |
| Issue: | 2 |
| ISSN: | 0161-5505 |
| Publisher: | Society of Nuclear Medicine |
| Date Published: | 2009-02-01 |
| Start Page: | 239 |
| End Page: | 249 |
| Language: | English |
| DOI: | 10.2967/jnumed.108.056655 |
| PUBMED: | 19164218 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 10" - "Export Date: 30 November 2010" - "CODEN: JNMEA" - "Source: Scopus" |
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