Somatostatin receptor imaging and theranostics: Current practice and future prospects Review
| Authors: | Park, S.; Parihar, A. S.; Bodei, L.; Hope, T. A.; Mallak, N.; Millo, C.; Prasad, K.; Wilson, D.; Zukotynski, K.; Mittra, E. |
| Review Title: | Somatostatin receptor imaging and theranostics: Current practice and future prospects |
| Abstract: | A new era of precision diagnostics and therapy for patients with neuroendocrine neoplasms began with the approval of somatostatin receptor (SSTR) radiopharmaceuticals for PET imaging followed by peptide receptor radionuclide therapy (PRRT). With the transition from SSTR-based g-scintigraphy to PET, the higher sensitivity of the latter raised questions regarding the direct application of the planar scintigraphy–based Krenning score for PRRT eligibility. Also, to date, the role of SSTR PET in response assessment and predicting outcome remains under evaluation. In this comprehensive review article, we discuss the current role of SSTR PET in all aspects of neuroendocrine neoplasms, including its relation to conventional imaging, selection of patients for PRRT, and the current understanding of SSTR PET–based response assessment. We also provide a standardized reporting template for SSTR PET with a brief discussion. COPYRIGHT ß 2021 by the Society of Nuclear Medicine and Molecular Imaging. |
| Keywords: | clinical feature; positron emission tomography; follow up; computer assisted tomography; practice guideline; risk factor; neuroendocrine tumor; disease severity; clinical effectiveness; somatostatin; somatostatin receptor; neuroendocrine neoplasms; maximum standardized uptake value; disease burden; prognosis; human; article; peptide receptor radionuclide therapy; 68ga-dotatate; theranostic nanomedicine; sstr; 68ga-dotanoc |
| Journal Title: | Journal of Nuclear Medicine |
| Volume: | 62 |
| Issue: | 10 |
| ISSN: | 0161-5505 |
| Publisher: | Society of Nuclear Medicine |
| Date Published: | 2021-10-01 |
| Start Page: | 1323 |
| End Page: | 1329 |
| Language: | English |
| DOI: | 10.2967/jnumed.120.251512 |
| PROVIDER: | scopus |
| PUBMED: | 34301785 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 December 2021 -- Source: Scopus |
