Imaging diagnostic and therapeutic targets: Human epidermal growth factor receptor 2 Journal Article


Authors: Gebhart, G.; Flamen, P.; De Vries, E. G. E.; Jhaveri, K.; Wimana, Z.
Article Title: Imaging diagnostic and therapeutic targets: Human epidermal growth factor receptor 2
Abstract: Since the approval of trastuzumab, a humanized monoclonal antibody against the extracellular domain of human epidermal growth factor receptor 2 (HER2), 3 other HER2-targeting agents have gained regulatory approval: lapatinib, pertuzumab, and trastuzumab-emtansine. These agents have revolutionized the management of HER2-positive breast cancer, highlighting the concept that targeted therapies are successful when patients exhibit tumor-selective expression of a molecular target-in this case, HER2. However, response prediction and innate or acquired resistance remain serious concerns. Predictive biomarkers of a response-which could help in the selection of patients who might benefit from a selected targeted therapy-are currently lacking. Molecular imaging with anti-HER2 probes allows the noninvasive, whole-body assessment of HER2 tumor burden and has the potential to improve patient selection, optimize the dose and schedule, and rationalize assessment of the response to anti-HER2 therapies. Furthermore, unlike biopsy-based HER2 assessment, this approach can reveal inter-or intratumoral heterogeneity as well as variations in HER2 expression over time. This review summarizes the available literature and the current status of molecular imaging as a tool for the assessment of HER2 (target) expression or the prediction of an early treatment response in early and advanced HER2-positive breast cancer. Copyright © 2016 by the Society of Nuclear Medicine and Molecular Imaging, Inc.
Keywords: molecular imaging; pet/ct; spect/ct; human epidermal growth factor receptor; breast oncology; her2 imaging
Journal Title: Journal of Nuclear Medicine
Volume: 57
Issue: Suppl. 1
ISSN: 0161-5505
Publisher: Society of Nuclear Medicine  
Date Published: 2016-02-01
Start Page: 81S
End Page: 88S
Language: English
DOI: 10.2967/jnumed.115.157941
PROVIDER: scopus
PUBMED: 26834107
DOI/URL:
Notes: Article -- Export Date: 3 March 2016 -- Source: Scopus
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  1. Komal Lachhman Jhaveri
    220 Jhaveri