A CERTain role for ceramide in taxane-induced cell death Journal Article
| Authors: | Kolesnick, R.; Altieri, D.; Fuks, Z. |
| Article Title: | A CERTain role for ceramide in taxane-induced cell death |
| Abstract: | An unexpected benefit of functional genomic screens is that at times they answer questions that they were not designed to ask. A siRNA screen reported by Swanton et al. in this issue of Cancer Cell reveals that silencing of spindle assembly checkpoint genes facilitates mitotic slippage, resulting in escape from taxane-induced cell death, aneuploidy, and chromosomal instability, hallmarks of taxane resistance. Unexpectedly, the screen disclosed that the sphingolipid ceramide is a key regulator of the taxane-mediated spindle assembly checkpoint and taxane-induced cell death. Ceramide metabolism thus serves as a legitimate target for modulation of taxane effect on tumors. © 2007 Elsevier Inc. All rights reserved. |
| Keywords: | protein kinase b; carrier protein; unclassified drug; paclitaxel; mitosis; cell death; apoptosis; stress activated protein kinase; small interfering rna; rna, small interfering; rna interference; antineoplastic activity; drug resistance, neoplasm; tumor cells, cultured; cancer resistance; cancer inhibition; endoplasmic reticulum; enzyme phosphorylation; protein-serine-threonine kinases; tumor necrosis factor related apoptosis inducing ligand; short survey; chromosomal instability; mitosis spindle; mitotic spindle apparatus; taxoids; taxane derivative; protein folding; aneuploidy; polyploidy; functional genomics; ceramide; ceramides; bridged compounds; growth arrest and dna damage inducible protein 153; phospholipid metabolism; apoptosis signal regulating kinase 1; ceramide transfer protein; initiation factor 2alpha |
| Journal Title: | Cancer Cell |
| Volume: | 11 |
| Issue: | 6 |
| ISSN: | 1535-6108 |
| Publisher: | Cell Press |
| Date Published: | 2007-06-01 |
| Start Page: | 473 |
| End Page: | 475 |
| Language: | English |
| DOI: | 10.1016/j.ccr.2007.05.003 |
| PUBMED: | 17560328 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 6" - "Export Date: 17 November 2011" - "CODEN: CCAEC" - "Source: Scopus" |
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