Electrophysiological features of taxane-induced polyneuropathy in patients with breast cancer Journal Article

  


Authors: Chen, X.; Stubblefield, M. D.; Custodio, C. M.; Hudis, C. A.; Seidman, A. D.; De Angelis, L. M.
Article Title: Electrophysiological features of taxane-induced polyneuropathy in patients with breast cancer
Abstract: SUMMARY: Fifty-five patients with breast cancer were analyzed for electrophysiological characteristics of taxane-induced polyneuropathy. Based on the electrodiagnostic criteria, sensory motor polyneuropathy was found in 67% (37/55) of patients ranging between mild degree and moderate to severe degree. The polyneuropathy is predominantly axonal with three unique features: (1) frequent asymmetry, (2) high sural and radial sensory amplitude ratio in patients with mild polyneuropathy, and (3) slow conduction velocity seen only at the common entrapment sites, such as the carpal tunnel. The severity of polyneuropathy correlated positively with the cumulative dose received. Our study supports the clinical utility of electrodiagnostic study in both diagnosis and monitoring of taxane-induced polyneuropathy.Copyright © 2013 by the American Clinical Neurophysiology Society.
Keywords: adult; aged; middle aged; paresthesia; antineoplastic agents; paclitaxel; chemotherapy; pain; breast cancer; neuropathy; breast neoplasms; disease severity; laboratory test; electromyography; taxoids; taxane derivative; navelbine; protein electrophoresis; electrophysiology; clinical examination; thyrotropin; cyanocobalamin; gait disorder; electrodiagnosis; taxane; neural conduction; hemoglobin a1c; polyneuropathy; electromyogram; polyneuropathies; nerve conduction study; motor unit
Journal Title: Journal of Clinical Neurophysiology
Volume: 30
Issue: 2
ISSN: 0736-0258
Publisher: American Clinical Neurophysiology Society  
Date Published: 2013-04-01
Start Page: 199
End Page: 203
Language: English
PROVIDER: scopus
PUBMED: 23545771
DOI: 10.1097/WNP.0b013e3182767d3b
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-84876400421&partnerID=40&md5=f0cf4d99d2504360ce509bbfb3d8aae4
Notes: --- - "Export Date: 1 May 2013" - "CODEN: JCNEE" - ":doi 10.1097/WNP.0b013e3182767d3b" - "Source: Scopus"
Altmetric
What is Altmetric?
Citation Impact
What is Dimensions Citation Badge?
BMJ Impact Analytics
MSK Authors
  1. Xi Chen
    31 Chen
  2. Lisa De Angelis
    576 De Angelis
  3. Andrew D Seidman
    318 Seidman
  4. Clifford Hudis
    905 Hudis
  5. Christian M Custodio
    24 Custodio
  6. Michael Stubblefield
    52 Stubblefield
Related MSK Work