Cells under tension drive gastrulation Editorial
| Authors: | Schwarz, C.; Hadjantonakis, A. K. |
| Title: | Cells under tension drive gastrulation |
| Abstract: | In this issue of Developmental Cell, Muncie et al. describe the generation of gastrulation-like foci of cells within micropatterned colonies of pluripotent stem cells. This demonstration of mechanosensitive β-catenin/Wnt-dependent specification of cell fate during gastrulation illustrates the insights gleaned by placing stem cells in embryo-like mechanical environments. © 2020 In this issue of Developmental Cell, Muncie et al. describe the generation of gastrulation-like foci of cells within micropatterned colonies of pluripotent stem cells. This demonstration of mechanosensitive β-catenin/Wnt-dependent specification of cell fate during gastrulation illustrates the insights gleaned by placing stem cells in embryo-like mechanical environments. © 2020 |
| Keywords: | protein phosphorylation; nonhuman; cell function; transcription factor; cell fate; cell motion; embryo development; cell differentiation; cell population; protein tyrosine kinase; uvomorulin; cell specificity; scleroprotein; cell culture; mammal; pluripotent stem cell; beta catenin; wnt protein; tension; mesoderm; zebra fish; endoderm; gastrulation; mechanotransduction; tissue culture; bone morphogenetic protein 4; hydrogel; human; priority journal; article; cells by body anatomy; organoid; human embryonic stem cell; polyacrylamide; cnidaria |
| Journal Title: | Developmental Cell |
| Volume: | 55 |
| Issue: | 6 |
| ISSN: | 1534-5807 |
| Publisher: | Cell Press |
| Date Published: | 2020-12-21 |
| Start Page: | 669 |
| End Page: | 670 |
| Language: | English |
| DOI: | 10.1016/j.devcel.2020.11.023 |
| PUBMED: | 33352138 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 February 2021 -- Source: Scopus |
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