Feasibility of multimodality therapy including extended resections in stage IVA thymoma Journal Article
| Authors: | Huang, J.; Rizk, N. P.; Travis, W. D.; Seshan, V. E.; Bains, M. S.; Dycoco, J.; Downey, R. J.; Flores, R. M.; Park, B. J.; Rusch, V. W. |
| Article Title: | Feasibility of multimodality therapy including extended resections in stage IVA thymoma |
| Abstract: | Objective: Extended resections for advanced-stage thymomas are not commonly performed because of the potential morbidity in the face of unclear survival or palliative benefit. We reviewed our experience with multimodality treatment for Masaoka stage IVA thymomas for feasibility and outcomes. Methods: We conducted a retrospective review of a single-institution surgical database. Data included patient demographics, preoperative staging and treatment, perioperative events, pathologic findings, and postoperative outcomes. Results: During the period from 1996 to 2006, 18 patients who had Masaoka stage IVA thymoma underwent surgical resection. All patients received preoperative chemotherapy. Four patients with extensive pleural involvement underwent concomitant extrapleural pneumonectomy and postoperative hemithoracic radiation. Complete resection was achieved in 12 (67%) patients. There was no operative mortality. With a median follow-up of 32.2 months (range 1.4-129.9 months), 3-year, 5-year, and 10-year survivals were 91%, 78%, and 65%, respectively, and median survival has not yet been reached. Conclusion: Multimodality therapy including extended surgical resection can be performed in select patients with stage IVA thymoma with low morbidity and mortality and can result in excellent long-term survival. © 2007 The American Association for Thoracic Surgery. |
| Keywords: | adult; cancer chemotherapy; cancer survival; clinical article; treatment outcome; aged; middle aged; cancer surgery; survival rate; retrospective studies; cisplatin; doxorubicin; multimodality cancer therapy; cancer radiotherapy; combined modality therapy; neoadjuvant therapy; radiotherapy, adjuvant; cancer staging; follow up; antineoplastic agent; neoplasm staging; demography; etoposide; lung resection; thoracotomy; antineoplastic combined chemotherapy protocols; pneumonectomy; cyclophosphamide; retrospective study; ifosfamide; postoperative complication; survival time; feasibility studies; perioperative period; thymoma; thymus neoplasms; pleural neoplasms |
| Journal Title: | Journal of Thoracic and Cardiovascular Surgery |
| Volume: | 134 |
| Issue: | 6 |
| ISSN: | 0022-5223 |
| Publisher: | Mosby Elsevier |
| Date Published: | 2007-12-01 |
| Start Page: | 1477 |
| End Page: | 1484 |
| Language: | English |
| DOI: | 10.1016/j.jtcvs.2007.07.049 |
| PUBMED: | 18023668 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 26" - "Export Date: 17 November 2011" - "CODEN: JTCSA" - "Source: Scopus" |
