Induction therapy for locally advanced thymoma Journal Article
| Authors: | Riely, G. J.; Huang, J. |
| Article Title: | Induction therapy for locally advanced thymoma |
| Abstract: | Thymomas are the most frequently encountered tumors of the mediastinum and often present with either localized or locally advanced disease. The prognosis in thymoma has been consistently shown to correspond to the invasiveness of the tumor (as represented by the Masaoka stage of the tumor) and the completeness of surgical resection. Because treatment with a variety of different chemotherapy regimens has demonstrated radiographic response rates greater than 50% in patients with advanced thymoma, a number of investigators have explored the use of preoperative (induction, neoadjuvant) therapy for patients with locally advanced thymoma. In this review, we summarize the published experience with preoperative therapy for thymoma and discuss ongoing clinical trials exploring multimodality therapy for treatment of locally advanced thymoma. © 2010 by the International Association for the Study of Lung Cancer. |
| Keywords: | cancer surgery; prednisone; review; cisplatin; doxorubicin; advanced cancer; cancer combination chemotherapy; clinical trials as topic; adjuvant therapy; cancer radiotherapy; combined modality therapy; chemotherapy; etoposide; epidermal growth factor receptor; cyclophosphamide; vincristine; cancer invasion; remission induction; epirubicin; thymoma; thymic carcinoma; thymus neoplasms |
| Journal Title: | Journal of Thoracic Oncology |
| Volume: | 5 |
| Issue: | 10 Suppl. 4 |
| ISSN: | 1556-0864 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2010-10-01 |
| Start Page: | S323 |
| End Page: | S326 |
| Language: | English |
| DOI: | 10.1097/JTO.0b013e3181f20e90 |
| PUBMED: | 20859127 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Export Date: 20 April 2011" - "Source: Scopus" |
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