Thymic carcinoma: Current staging does not predict prognosis Conference Paper
| Authors: | Blumberg, D.; Burt, M. E.; Bains, M. S.; Downey, R. J.; Martini, N.; Rusch, V.; Ginsberg, R. J. |
| Title: | Thymic carcinoma: Current staging does not predict prognosis |
| Conference Title: | 77th Annual Meeting of the American Association for Thoracic Surgery |
| Abstract: | Background: Thymic carcinomas are currently staged by Masaoka classification, a staging system for thymomas. We retrospectively evaluated surgical patients with thymic carcinoma to determine prognostic factors and to evaluate the usefulness of Masaoka staging in this disease. Methods: Our computerized tumor registry yielded 118 patients with thymoma. Review of pathologic material revealed 43 cases of thymic carcinoma. Collection of data was by review of hospital and physician charts and telephone contact with patients. Analysis of prognostic factors was performed in patients undergoing complete resection by the method of Kaplan-Meier and Cox proportional hazards regression. Results: Between 1949 and 1993, 43 patients underwent surgery for thymic carcinoma. Overall survival was 65% at 5 years and 35% at 10 years. Overall recurrence was 65% at 5 years and 75% at 10 years. On univariate analysis, survival was not dependent on age, sex, tumor size, or Masaoka stage but was dependent on innominate vessel invasion. By multivariate analysis, survival was dependent only on innominate vessel invasion. Conclusions: Patients with thymic carcinoma have a high rate of recurrence. Tumor invasion of the innominate vessels is associated with a particularly poor prognosis. Although Masaoka staging is useful in staging patients with thymoma, it does not appear to predict outcome for patients with thymic carcinoma. |
| Keywords: | adult; cancer survival; clinical article; treatment outcome; aged; middle aged; retrospective studies; cancer recurrence; disease classification; cancer staging; neoplasm staging; proportional hazards models; risk factors; recurrence; cancer invasion; predictive value of tests; neoplasm invasiveness; thymoma; thymus neoplasms; humans; prognosis; human; male; female; priority journal; article |
| Journal Title | Journal of Thoracic and Cardiovascular Surgery |
| Volume: | 115 |
| Issue: | 2 |
| Conference Dates: | 1997 May 4-7 |
| Conference Location: | Washington, DC |
| ISBN: | 0022-5223 |
| Publisher: | Mosby Elsevier |
| Date Published: | 1998-02-01 |
| Start Page: | 303 |
| End Page: | 308; discussion 308-309 |
| Language: | English |
| DOI: | 10.1016/s0022-5223(98)70273-9 |
| PUBMED: | 9475524 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 12 December 2016 -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work