The role of iodine-124-positron emission tomography imaging in the management of patients with thyroid cancer Journal Article
| Authors: | Grewal, R. K.; Lubberink, M.; Pentlow, K. S.; Larson, S. M. |
| Article Title: | The role of iodine-124-positron emission tomography imaging in the management of patients with thyroid cancer |
| Abstract: | Molecular imaging is the visualization, characterization, and measurement of biologic processes at the molecular and cellular levels in human beings and other living systems. In thyroid cancer, this includes imaging iodine transport, which is active in about 80% of well-differentiated thyroid malignancies. Iodine-124 imaging with positron emission tomography (I-124-PET) is ideal for this purpose because PET provides tomographic images with spatial and contrast resolution. Because iodine-131 is the mainstay for therapy in thyroid cancer, and because success or failure of therapy depends on the degree of iodine uptake by the tumor cells, I-124-PET imaging will increasingly act as a surrogate for this treatment. This approach may serve as a model for individualized therapeutic interventions for many other malignant and nonmalignant diseases. © 2008 Elsevier Inc. All rights reserved. |
| Keywords: | aged; review; case report; positron emission tomography; diagnostic accuracy; molecular imaging; iodine 131; drug uptake; diagnostic value; dosimetry; image quality; cancer cell; iodine 124; thyroid cancer; iodine 123; 3 iodobenzoic acid |
| Journal Title: | PET Clinics |
| Volume: | 2 |
| Issue: | 3 |
| ISSN: | 1556-8598 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2007-07-01 |
| Start Page: | 313 |
| End Page: | 320 |
| Language: | English |
| DOI: | 10.1016/j.cpet.2008.05.001 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 2" - "Export Date: 17 November 2011" - "Source: Scopus" |
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