Imaging of differentiated thyroid cancer with iodine-124 and F-18-FDG Book Section
| Authors: | Nagarajah, J.; Jentzen, W.; Stebner, V.; Binse, I.; Janssen, M.; Grewal, R. K. |
| Editors: | Luster, M.; Duntas, L. H.; Wartofsky, L. |
| Article/Chapter Title: | Imaging of differentiated thyroid cancer with iodine-124 and F-18-FDG |
| Abstract: | Positron emission tomography (PET) is an established imaging device in oncological clinical setting using several isotope-labeled compounds of which I-124 and F-18-labeled fluorodeoxyglucose (FDG) are the most relevant ones for imaging of patients with differentiated thyroid cancer (DTC). Whereas I-124 PET is applied to identify thyroid cancer cells expressing the sodium-iodine symporter (NIS) which is correlated to a well-differentiated phenotype, F-18-FDG PET reveals thyroid cancer cells with a higher level of dedifferentiated feature with a more aggressive phenotype. Besides imaging NIS, I-124 PET enables a dosimetry approach to calculate radiation doses delivered to target lesions. In this chapter, we discuss the role of these two imaging techniques in thyroid cancer patients. © 2025 Elsevier B.V., All rights reserved. |
| Keywords: | positron emission tomography; medical imaging; dosimetry; medical computing; diseases; iodine; differentiated thyroid cancer; positron emission; emission tomography; finite difference method; fluorodeoxyglucose-positron emission tomographies; dtc; i-124 pet/ct; thyroid cancers; f-18 fdg pet/ct; i-124 pet/mri; f-18 fluorodeoxyglucose positron emission tomography/ct; i-124 positron emission tomography/ct; i-124 positron emission tomography/mri |
| Book Title: | The Thyroid and Its Diseases - A Comprehensive Guide for the Clinician |
| ISBN: | 978-3-319-72100-2 |
| Publisher: | Springer Science + Business Media, LLC |
| Publication Place: | Cham, Switzerland |
| Date Published: | 2019-01-01 |
| Start Page: | 199 |
| End Page: | 204 |
| Language: | English |
| DOI: | 10.1007/978-3-319-72102-6_13 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Book Chapter, located in "Part III - Diagnostic and Therapeutic Approaches" -- Source: Scopus |
