Polypodium leucotomos extract: A nutraceutical with photoprotective properties Journal Article

Authors: Gonzalez, S.; Alonso-Lebrero, J. L.; Del Rio, R.; Jaén, P.
Article Title: Polypodium leucotomos extract: A nutraceutical with photoprotective properties
Abstract: Ultraviolet (UV) irradiation causes multifaceted damage to the skin and adjacent tissue layers, and is one of the leading causes of premature skin aging, immunosuppression and carcinogenesis. Photoprotection can be achieved by the use of sunscreens and also by systemically administered compounds that fight the deleterious biological effects of UV exposure, or preferably both. In this review, we summarize the current knowledge on the tissue, cellular and molecular mechanisms underlying the photoprotective effect of Polypodium leucotomos fern extract. P. leucotomos blocked the deleterious effect of UV irradiation both in vivo and in vitro. The molecular basis of photoprotection relies on its ability to inhibit free radical generation, prevent photodecomposition of both endogenous photoprotective molecules and DNA, and prevent UV-induced cell death. Its complete loss of toxicity combined with its multifactor protection makes it a valuable tool not only for direct photoprotection, but also as an efficacious adjuvant to phototherapy of various skin diseases. © 2007 Prous science. All rights reserved.
Keywords: unclassified drug; review; nonhuman; mass spectrometry; animals; cell death; dna damage; drug inhibition; sunscreen; drug effect; radiation exposure; carcinogenesis; immunoregulation; pruritus; skin; drug mechanism; erythema; skin disease; plant extracts; antioxidants; drug metabolism; drug absorption; immunosuppressive treatment; ultraviolet rays; sunscreening agents; infection sensitivity; sunburn; polypodium leucotomos extract; photoaging; ultraviolet irradiation; polypodium; cutaneous parameters; psoralen; lethal dose; plant leaves; phototherapy; heliocare; photodegradation
Journal Title: Drugs of Today
Volume: 43
Issue: 7
ISSN: 1699-3993
Publisher: Prous Science  
Date Published: 2007-07-01
Start Page: 475
End Page: 485
Language: English
DOI: 10.1358/dot.2007.43.7.1062667
PUBMED: 17728848
PROVIDER: scopus
Notes: --- - "Cited By (since 1996): 10" - "Export Date: 17 November 2011" - "CODEN: MDACA" - "Source: Scopus"
Citation Impact
MSK Authors
  1. Salvador Gonzalez Rodriguez
    202 Rodriguez