Polypodium leucotomos extract: A natural antioxidant and photoprotective tool for the management of UV-induced skin damage and phototherapy Journal Article

  


Author: Gonzalez, S.
Article Title: Polypodium leucotomos extract: A natural antioxidant and photoprotective tool for the management of UV-induced skin damage and phototherapy
Abstract: The main causal agent of skin aging, immune depression, and cancer is UV light. Photoprotective agents can be divided into 2 classes: those that prevent photon-induced damage (sunscreens) and those that counter the deleterious effects of UV exposure systemically. In this review, the cellular and molecular mechanisms underlying the photoprotective effects of a Polypodium leucotomos (PL) fern extract are outlined. The effects of PL have been characterized in vivo and in vitro. It inhibits generation of reactive oxygen species and prevents UV-induced DNA damage, isomerization, decomposition of trans-urocanic acid, and also UV-induced cell death. Furthermore, oral treatment with PL combined with narrowband UVB therapy significantly promotes repigmentation of patients with vitiligo. Together, these effects postulate PL as a natural photoprotectant and potential adjuvant to phototherapy of various skin diseases. Copyright Cosmetic Dermatology 2010.
Journal Title: Cosmetic Dermatology
Volume: 22
Issue: 12
ISSN: 1041-3766
Publisher: Frontline Medical Communications, Inc.  
Date Published: 2009-12-01
Start Page: 604
End Page: 609
Language: English
PROVIDER: scopus
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-80053381001&partnerID=40&md5=04deb714d5043281ab7581e1f841d86f
Notes: --- - "Export Date: 2 November 2011" - "CODEN: CDOEB" - "Source: Scopus"