Squamous cell carcinoma arising in mature cystic teratoma of the ovary: A case series and review of the literature Journal Article

  


Authors: Dos Santos, L.; Mok, E.; Iasonos, A.; Park, K.; Soslow, R. A.; Aghajanian, C.; Alektiar, K.; Barakat, R. R.; Abu-Rustum, N. R.
Article Title: Squamous cell carcinoma arising in mature cystic teratoma of the ovary: A case series and review of the literature
Abstract: Objectives.: Malignant transformation of mature cystic teratomas is rare, with squamous cell carcinoma being the most common type. The prognosis is generally poor when disease has spread beyond the ovary. We conducted this study to review our experience with this disease and describe our current treatment modality. Methods.: During a 22-year period (1983-2005), we identified 17 women treated for squamous cell carcinoma arising in a mature cystic teratoma of the ovary. All pathologic diagnoses were confirmed at our institution. A retrospective chart review and comprehensive review of the literature were conducted. Results.: The median age was 55 (mean, 54.8; range, 37-75). Eight cases were stage I, 5 were stage II, and 4 were stage III. Mean tumor size was 14.2 cm. All patients underwent surgery, with positive lymph nodes noted in 0 of 10 cases that included lymph node dissection. Ten patients received adjuvant treatment-6 with chemotherapy and 4 with chemoradiation. Six patients had recurrent disease in the pelvis after adjuvant treatment. Four patients died of disease. The overall 1-year survival rate was 60%. The 4 patients with stages IA-IIB disease treated with adjuvant platinum-based chemotherapy and radiation survived at 12-56 months' follow-up. Conclusions.: Squamous carcinomas arising in mature cystic teratomas are commonly large ovarian tumors that occur in perimenopausal women and often present as an incidental pathologic finding. While the prognosis seems highly dependent on surgical stage, there is a lack of consensus in the literature regarding adjuvant treatment. Platinum-based chemotherapy with pelvic radiation may be a reasonable adjuvant therapy for early-stage disease. © 2006 Elsevier Inc. All rights reserved.
Keywords: adult; cancer survival; clinical article; aged; middle aged; survival rate; retrospective studies; overall survival; mortality; cancer recurrence; squamous cell carcinoma; carcinoma, squamous cell; cisplatin; fluorouracil; gemcitabine; paclitaxel; adjuvant therapy; chemotherapy, adjuvant; radiotherapy, adjuvant; cancer staging; follow up; lymph node dissection; lymph nodes; pelvis; ovarian cancer; ovarian neoplasms; carboplatin; tumor volume; etoposide; retrospective study; cell transformation, neoplastic; adjuvant chemotherapy; ovary tumor; bleomycin; mitomycin c; platinum; vindesine; teratoma; incidental finding; ovary teratoma; malignant transformation; climacterium; rare disease; malignant teratoma; ovarian teratoma; squamous carcinoma in dermoid
Journal Title: Gynecologic Oncology
Volume: 105
Issue: 2
ISSN: 0090-8258
Publisher: Elsevier Inc.  
Date Published: 2007-05-01
Start Page: 321
End Page: 324
Language: English
DOI: 10.1016/j.ygyno.2006.12.008
PUBMED: 17240432
PROVIDER: scopus
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-34247163605&partnerID=40&md5=42527bc9a960e8aea0040d9872c5b5e5
Notes: --- - "Cited By (since 1996): 35" - "Export Date: 17 November 2011" - "CODEN: GYNOA" - "Source: Scopus"
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MSK Authors
  1. Richard R Barakat
    629 Barakat
  2. Kaled M Alektiar
    333 Alektiar
  3. Nadeem Abu-Rustum
    888 Abu-Rustum
  4. Alexia Elia Iasonos
    362 Iasonos
  5. Kay Jung Park
    305 Park
  6. Robert Soslow
    793 Soslow
  7. Lisa Dos Santos
    9 Dos Santos
  8. Carol A Aghajanian
    607 Aghajanian
  9. Evelyn Mok
    1 Mok
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