Long-term survival after fertility-sparing surgery for epithelial ovarian cancer Journal Article
| Authors: | Schlaerth, A. C.; Chi, D. S.; Poynor, E. A.; Barakat, R. R.; Brown, C. L. |
| Article Title: | Long-term survival after fertility-sparing surgery for epithelial ovarian cancer |
| Abstract: | Objective: To determine the long-term results of fertility-sparing surgery in the treatment of early-stage invasive epithelial ovarian cancer. Methods: A retrospective review of 123 patients who underwent surgical staging for FIGO stage I epithelial ovarian cancer from November 1982 to July 2002. Demographics, stage, histopathology, adjuvant therapy, recurrence, and survival were compared for patients who had fertility-sparing surgery and for those having standard surgical staging. Results: Twenty patients, with a median age of 27 years, had preservation of the uterus and contralateral ovary at the time of surgical staging. Platinum-based chemotherapy was administered to 50% of these patients postoperatively. Three patients (15%) recurred in the retained ovary at 9, 20, and 22 months, and all died of their disease. One patient was diagnosed with primary endometrial cancer at 15 months and was salvaged with hysterectomy. At a median follow-up of 122 months, 17 (85%) of 20 patients treated with fertility-sparing surgery were alive without disease. Of the 103 patients treated with removal of the uterus and both ovaries, 72% received adjuvant platinum chemotherapy. Twenty (19%) of the patients in the standard surgery group have recurred, and 17 have died of disease. At a median follow-up of 113 months, 78 (76%) of 103 patients treated with standard surgery were alive without disease. Five-year survival data showed no significant difference in the recurrence-free survival of the fertility-sparing and standard surgery groups (84% vs 78%) or overall survival (84% vs 82%). Conclusion: Fertility-sparing surgery is a reasonable alternative treatment for young women with stage I epithelial ovarian cancer desiring fertility preservation. Copyright © 2009 by IGCS and ESGO. |
| Keywords: | survival; cancer chemotherapy; controlled study; human tissue; treatment outcome; survival analysis; primary tumor; surgical technique; retrospective studies; major clinical study; overall survival; histopathology; mortality; review; paclitaxel; adjuvant therapy; cancer adjuvant therapy; cancer radiotherapy; comparative study; chemotherapy, adjuvant; radiotherapy, adjuvant; cancer staging; recurrent cancer; follow up; antineoplastic agent; hysterectomy; endometrium cancer; salpingooophorectomy; neoplasm; ovarian neoplasms; carboplatin; multiple cycle treatment; ovary cancer; statistics; recurrence; age factors; pathology; retrospective study; cancer mortality; survivor; age; survivors; cancer invasion; survival time; evaluation; adjuvant chemotherapy; ovary tumor; recurrent disease; organ preservation; abdominal hysterectomy; infertility, female; female infertility; fertility-sparing surgery; stage i ovarian carcinoma; surgical staging; fertility sparing surgery; neoplasms, glandular and epithelial |
| Journal Title: | International Journal of Gynecological Cancer |
| Volume: | 19 |
| Issue: | 7 |
| ISSN: | 1048-891X |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 2009-10-01 |
| Start Page: | 1199 |
| End Page: | 1204 |
| Language: | English |
| DOI: | 10.1111/IGC.0b013e31819d82c3 |
| PUBMED: | 19823055 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 1" - "Export Date: 30 November 2010" - "CODEN: IJGCE" - "Source: Scopus" |
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