A retrospective multicenter study of fatal pediatric melanoma Journal Article
| Authors: | Hawryluk, E. B.; Moustafa, D.; Bartenstein, D.; Brahmbhatt, M.; Cordoro, K.; Gardner, L.; Gauthier, A.; Grossman, D.; Gupta, D.; Hunt, R. D.; Jen, M.; Kao, P. C.; Kruse, L. L.; Lawley, L. P.; London, W. B.; Mansour, D.; O'Haver, J. A.; Phung, T.; Pope, E.; Price, H. N.; Rogers, T.; Shah, S. D.; Wolner, Z.; Huang, J.; Marghoob, A. A. |
| Article Title: | A retrospective multicenter study of fatal pediatric melanoma |
| Abstract: | Background: Pediatric melanoma is rare and diagnostically challenging. Objective: To characterize clinical and histopathologic features of fatal pediatric melanomas. Methods: Multicenter retrospective study of fatal melanoma cases in patients younger than 20 years diagnosed between 1994 and 2017. Results: Of 38 cases of fatal pediatric melanoma identified, 57% presented in white patients and 19% in Hispanic patients. The average age at diagnosis was 12.7 years (range, 0.0-19.9 y), and the average age at death was 15.6 years (range, 1.2-26.2 y). Among cases with known identifiable subtypes, 50% were nodular (8/16), 31% were superficial spreading (5/16), and 19% were spitzoid melanoma (3/16). One fourth (10/38) of melanomas arose in association with congenital melanocytic nevi. Limitations: Retrospective nature, cohort size, and potential referral bias. Conclusions: Pediatric melanoma can be fatal in diverse clinical presentations, including a striking prevalence of Hispanic patients compared to adult disease, and with a range of clinical subtypes, although no fatal cases of spitzoid melanoma were diagnosed during childhood. © 2020 American Academy of Dermatology, Inc. |
| Keywords: | melanoma; oncology; pediatric melanoma; pediatric dermatology |
| Journal Title: | Journal of the American Academy of Dermatology |
| Volume: | 83 |
| Issue: | 5 |
| ISSN: | 0190-9622 |
| Publisher: | Mosby Elsevier |
| Date Published: | 2020-11-01 |
| Start Page: | 1274 |
| End Page: | 1281 |
| Language: | English |
| DOI: | 10.1016/j.jaad.2020.06.1010 |
| PUBMED: | 32622142 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 2 November 2020 -- Source: Scopus |
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