Risk factors and outcomes of melanoma in children and adolescents: A retrospective multicenter study Journal Article
| Authors: | Hawryluk, E. B.; Moustafa, D.; Barry, K. K.; Bahrani, E.; Reusch, D. B.; Brahmbhatt, M.; Chen, L.; Coughlin, C. C.; Gerami, P.; Haddock, E.; Hook, K.; Humphrey, S. R.; Kao, P. C.; Kruse, L. L.; Lawley, L. P.; Mansour, D.; Marghoob, A. A.; Nguyen, J.; Phung, T. L.; Pope, E.; Raisanen, T.; Robinson, S.; Rogers, T.; Schmidt, B.; Tran, G.; Travis, K.; Wolner, Z.; London, W. B.; Eichenfield, L. F.; Huang, J. |
| Article Title: | Risk factors and outcomes of melanoma in children and adolescents: A retrospective multicenter study |
| Abstract: | Background: Pediatric melanoma presents with distinct clinical features compared to adult disease. Objective: Characterize risk factors and negative outcomes in pediatric melanoma. Methods: Multicenter retrospective study of patients under 20 years diagnosed with melanoma between January 1, 1995 and June 30, 2015 from 11 academic medical centers. Results: Melanoma was diagnosed in 317 patients, 73% of whom were diagnosed in adolescence (age ≥11). Spitzoid (31%) and superficial spreading (26%) subtypes were most common and 11% of cases arose from congenital nevi. Sentinel lymph node biopsy was performed in 68% of cases and positive in 46%. Fatality was observed in 7% of cases. Adolescent patients with melanoma were more likely to have family history of melanoma (P = .046) compared to controls. Limitations: Retrospective nature, cohort size, control selection, and potential referral bias. Conclusion: Pediatric melanoma has diverse clinical presentations. Better understanding of these cases and outcomes may facilitate improved risk stratification of pediatric melanoma. © 2024 |
| Keywords: | adolescent; cancer chemotherapy; cancer survival; child; controlled study; cancer surgery; excision; major clinical study; clinical feature; histopathology; interferon; cancer risk; cancer radiotherapy; comparative study; antineoplastic agent; lymph node dissection; sentinel lymph node biopsy; interleukin 2; melanoma; malignant lentigo; cohort analysis; oncology; retrospective study; risk factor; risk assessment; infant; multicenter study; family history; newborn; drug therapy; university hospital; xeroderma pigmentosum; voriconazole; patient referral; congenital nevus; skin surgery; superficial spreading melanoma; fatality; dermatologist; b raf kinase inhibitor; adult disease; dysplastic nevus syndrome; pediatric surgery; pediatric melanoma; immune checkpoint inhibitor; cancer prognosis; non melanoma skin cancer; breslow thickness; lymph vessel metastasis; spitzoid melanoma; human; male; female; article; acral lentiginous melanoma; pediatric dermatology; checkpoint inhibitor therapy; special situation for pharmacovigilance; oculocutaneous albinism |
| Journal Title: | Journal of the American Academy of Dermatology |
| Volume: | 90 |
| Issue: | 4 |
| ISSN: | 0190-9622 |
| Publisher: | Mosby Elsevier |
| Date Published: | 2024-04-01 |
| Start Page: | 716 |
| End Page: | 726 |
| Language: | English |
| DOI: | 10.1016/j.jaad.2023.10.067 |
| PUBMED: | 38040338 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Source: Scopus |
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