Early-stage non-Spitzoid cutaneous melanoma in patients younger than 22 years of age at diagnosis: Long-term follow-up and survival analysis Journal Article
| Authors: | Stanelle, E. J.; Busam, K. J.; Rich, B. S.; Christison-Lagay, E. R.; Dunkel, I. J.; Marghoob, A. A.; Halpern, A.; Coit, D. G.; La Quaglia, M. P. |
| Article Title: | Early-stage non-Spitzoid cutaneous melanoma in patients younger than 22 years of age at diagnosis: Long-term follow-up and survival analysis |
| Abstract: | Purpose We evaluated prognostic factors among young patients with early stage melanoma, with particular attention to survival, recurrence, and development of a second primary melanoma. Methods We retrospectively reviewed patients (age < 22 years) with pathologically confirmed in-situ and stage 1 non-Spitzoid melanoma treated at our institution from 1980-2010, assessing demographics, clinical presentation, treatment, disease-specific survival, recurrence-free survival, and probability of developing a second primary melanoma. Results One hundred patients with in-situ melanoma (n = 16) or stage 1A (n = 48) or 1B (n = 36) melanoma were identified. Median age was 19.4 years (range, 11.2-21.9), and median follow-up was 7.6 years (range, 0.1-31.7). Median tumor thickness was 0.76 mm (range, 0.23-2.0). No lesions were ulcerated. All patients underwent wide local excision with negative margins, and 21 had a concomitant negative sentinel lymph node biopsy (SLNB). Sixteen patients developed recurrences, and 8 subsequently died of progressive melanoma. There were 2 non-melanoma-related deaths. Endpoints were 20-year overall survival (77.4%), melanoma-specific mortality (20.1%), recurrence rate (34.0%), and probability of developing a second primary melanoma (24.7%). Greater tumor depth and Clark level were associated with worse prognosis, but age, sex, and tumor mitotic rate were not correlated with recurrence or survival. Conclusion Among younger early-stage melanoma patients, greater lesion depth conferred higher recurrence risk and mortality. Our data did not define the role of sentinel lymph node biopsy in this group. © 2015 Elsevier Inc. All rights reserved. |
| Keywords: | adolescent; melanoma; recurrence; prognosis |
| Journal Title: | Journal of Pediatric Surgery |
| Volume: | 50 |
| Issue: | 6 |
| ISSN: | 0022-3468 |
| Publisher: | W.B. Saunders Co-Elsevier Inc. |
| Date Published: | 2015-06-01 |
| Start Page: | 1019 |
| End Page: | 1023 |
| Language: | English |
| DOI: | 10.1016/j.jpedsurg.2015.03.030 |
| PROVIDER: | scopus |
| PUBMED: | 25819019 |
| PMCID: | PMC4558908 |
| DOI/URL: | |
| Notes: | Export Date: 3 June 2015 -- Source: Scopus |
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