Cognitive functions in low-grade gliomas: Disease and treatment effects Journal Article

  


Authors: Correa, D. D.; Deangelis, L. M.; Shi, W.; Thaler, H. T.; Lin, M.; Abrey, L. E.
Article Title: Cognitive functions in low-grade gliomas: Disease and treatment effects
Abstract: Background: The role of radiotherapy and chemotherapy in the treatment of low-grade gliomas (LGG) is controversial regarding their effect on survival and the development of neurotoxicity. The few published studies examining adverse treatment effects on cognition revealed conflicting results. Objective: To assess cognitive functioning in LGG patients who received conformal radiation therapy (RT), chemotherapy, or no treatment. Design: 40 LGG patients participated in the study; 16 patients had RT ± chemotherapy, and 24 patients had no treatment. All patients underwent a neuropsychological evaluation. APOE genotype was obtained in 36 patients who were classified in two groups based on the presence or absence of at least one apolipoprotein E ε-4 (APOE ε-4) allele. Results: Treated LGG patients had lower scores than untreated patients on several cognitive domains; patients who completed treatment at intervals greater than 3 years and had long disease duration had significantly lower scores on the Non-Verbal Memory domain. Antiepileptic polytherapy, treatment history, and disease duration jointly contributed to low Psychomotor domain scores. 62% of treated patients showed white matter confluence on MRI, whereas only 9% of the untreated patients had such changes. Preliminary comparisons between APOE ε-4 carriers (n = 9) and non-carriers (n = 27) on cognitive domain scores revealed no statistically significant differences, but APOE ε-4 carriers had lower mean scores on the Verbal Memory domain than did non-ε-4 carriers. Conclusions: RT ± chemotherapy, disease duration, and antiepileptic treatment contributed to mild cognitive difficulties in LGG patients. © Springer Science+Business Media B.V. 2006.
Keywords: adult; clinical article; controlled study; treatment outcome; middle aged; antineoplastic agents; chemotherapy; nuclear magnetic resonance imaging; glioma; brain neoplasms; antineoplastic agent; cancer grading; allele; carboplatin; quality of life; radiation; genotype; vincristine; lomustine; procarbazine; scoring system; neuropsychological tests; cognition; cognitive defect; disease duration; cognitive; anticonvulsive agent; verbal memory; cognition disorders; epilepsy; computer assisted radiotherapy; drug utilization; phenytoin; white matter; neurologic examination; psychologic assessment; carbamazepine; memory consolidation; neuropsychology; apolipoprotein e; low-grade glioma; beck depression inventory; apolipoprotein e4
Journal Title: Journal of Neuro-Oncology
Volume: 81
Issue: 2
ISSN: 0167-594X
Publisher: Springer  
Date Published: 2007-01-01
Start Page: 175
End Page: 184
Language: English
DOI: 10.1007/s11060-006-9212-3
PUBMED: 16850104
PROVIDER: scopus
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-33845701214&partnerID=40&md5=672e0b22777106707346e414de086e35
Notes: --- - "Cited By (since 1996): 18" - "Export Date: 17 November 2011" - "CODEN: JNODD" - "Source: Scopus"
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MSK Authors
  1. Lisa De Angelis
    563 De Angelis
  2. Weiji Shi
    121 Shi
  3. Denise D Correa
    81 Correa
  4. Lauren E Abrey
    277 Abrey
  5. Howard T Thaler
    245 Thaler
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