A pilot study of neuropsychological functions, APOE and amyloid imaging in patients with gliomas Journal Article


Authors: Correa, D. D.; Kryza-Lacombe, M.; Zhou, X.; Baser, R. E.; Beattie, B. J.; Beiene, Z.; Humm, J.; DeAngelis, L. M.; Orlow, I.; Weber, W.; Osborne, J.
Article Title: A pilot study of neuropsychological functions, APOE and amyloid imaging in patients with gliomas
Abstract: Brain tumor patients treated with radiotherapy (RT) often develop cognitive dysfunction, and recent studies suggest that the APOE ε-4 allele may influence cognitive outcome. The ε-4 allele is known to promote beta (β) amyloid deposition in the cortex, and preliminary evidence suggests that RT may be associated with this process. However, it is unknown whether β-amyloid accumulation contributes to treatment neurotoxicity. In this pilot study, we assessed neuropsychological functions and β-amyloid retention using 18F-florbetaben (FBB) PET in a subset of brain tumor patients who participated in our study of APOE polymorphisms and cognitive functions. Twenty glioma patients treated with conformal RT ± chemotherapy participated in the study: 6 were APOE ε-4 carriers and 14 were non-ε-4 carriers. Patients completed a neuropsychological re-evaluation (mean time interval = 5 years, SD = 0.83) and brain MRI and FBB PET scans. Wilcoxon signed-rank test comparisons between prior and current neuropsychological assessments showed a significant decline in attention (Brief Test of Attention, p = 0.018), and a near significant decline in verbal learning (Hopkins Verbal learning Test-Learning, p = 0.07). Comparisons by APOE status showed significant differences over time in attention/working memory (WAIS-III digits forward, p = 0.028 and digits backward, p = 0.032), with a decline among APOE ε-4 carriers. There were no significant differences in any of the FBB PET analyses between APOE ε-4 carriers and non-ε-4 carriers. The findings suggest that glioma patients may experience worsening in attention and executive functions several years after treatment, and that the APOE ε-4 allele may modulate cognitive decline, but independent of increased β-amyloid deposition. © 2017, Springer Science+Business Media, LLC, part of Springer Nature.
Keywords: cognitive; brain tumors; amyloid; apoe
Journal Title: Journal of Neuro-Oncology
Volume: 136
Issue: 3
ISSN: 0167-594X
Publisher: Springer  
Date Published: 2018-02-01
Start Page: 613
End Page: 622
Language: English
DOI: 10.1007/s11060-017-2692-5
PROVIDER: scopus
PMCID: PMC5807139
PUBMED: 29168082
DOI/URL:
Notes: Article -- Export Date: 1 March 2018 -- Source: Scopus
Altmetric Score
MSK Authors
  1. Raymond E Baser
    65 Baser
  2. Joseph R Osborne
    56 Osborne
  3. Denise D Correa
    65 Correa
  4. Irene Orlow
    191 Orlow
  5. John Laurence Humm
    339 Humm
  6. Bradley Beattie
    106 Beattie
  7. Wolfgang Andreas Weber
    147 Weber
  8. Xiaosun Zhou
    3 Zhou
  9. Zodina Beiene
    2 Beiene