Longitudinal cognitive follow-up in low grade gliomas Journal Article

Authors: Correa, D. D.; Shi, W.; Thaler, H. T.; Cheung, A. M.; Deangelis, L. M.; Abrey, L. E.
Article Title: Longitudinal cognitive follow-up in low grade gliomas
Abstract: Background: In patients with low-grade glioma (LGG), the tumor and its treatment with conformal radiation therapy (RT) and chemotherapy can disrupt cognitive function. However, the contribution of disease and treatment to long-term cognitive outcome remains to be elucidated. In this study, we performed longitudinal cognitive follow-up in a subgroup of patients who received RT, chemotherapy, or no treatment. Methods: Twenty-five LGG patients underwent neuropsychological evaluations at study entry, and 6 and 12 months subsequently; 9 patients had RT ± chemotherapy prior to enrollment and 16 had no treatment. Results: At the initial evaluation, treated patients had impaired performance on motor speed only, but scored 1 standard deviation below normative values on tests of executive functions; untreated patients had no cognitive impairment. Repeated measures analyses of variance showed a significant variation over time (P = 0.03) in nonverbal memory (delayed recall); treated patients' performance improved at the 6-month follow-up to a level comparable to untreated patients, but both groups declined slightly by the 12-month evaluation. In a subset of patients (N = 16) available for an additional cognitive evaluation, significant changes between the 12-month and the long-term follow-up were seen in phonemic verbal fluency, mood and quality of life; untreated patients seen at short intervals improved slightly while treated patients seen at longer intervals declined. Conclusions: Longitudinal follow-up showed that both disease duration and treatment with RT ± chemotherapy contributed to a mild decrement in nonverbal recall and in some aspects of executive functions and quality of life in this group of LGG patients. © Springer Science+Business Media, LLC. 2007.
Keywords: adult; clinical article; human tissue; middle aged; functional assessment; case-control studies; treatment duration; cancer radiotherapy; chemotherapy, adjuvant; chemotherapy; follow up; glioma; brain neoplasms; magnetic resonance imaging; antineoplastic agent; cancer grading; carboplatin; quality of life; radiation; vincristine; lomustine; procarbazine; time factors; mood; statistical analysis; longitudinal studies; neuropsychological test; neuropsychological tests; cognition; cognitive defect; disease duration; seizure; radiotherapy, conformal; cognitive; anticonvulsive agent; memory disorder; motor performance; verbal memory; brain biopsy; longitudinal study; neuropsychology; low-grade glioma
Journal Title: Journal of Neuro-Oncology
Volume: 86
Issue: 3
ISSN: 0167-594X
Publisher: Springer  
Date Published: 2008-02-01
Start Page: 321
End Page: 327
Language: English
DOI: 10.1007/s11060-007-9474-4
PUBMED: 17926007
PROVIDER: scopus
Notes: --- - "Cited By (since 1996): 16" - "Export Date: 17 November 2011" - "CODEN: JNODD" - "Source: Scopus"
Citation Impact
MSK Authors
  1. Weiji Shi
    121 Shi
  2. Denise D Correa
    78 Correa
  3. Lauren E Abrey
    276 Abrey
  4. Howard T Thaler
    245 Thaler