Longitudinal cognitive assessment in patients with primary CNS lymphoma treated with induction chemotherapy followed by reduced-dose whole-brain radiotherapy or autologous stem cell transplantation Journal Article

   

Authors:	Correa, D. D.; Braun, E.; Kryza-Lacombe, M.; Ho, K. W.; Reiner, A. S.; Panageas, K. S.; Yahalom, J.; Sauter, C. S.; Abrey, L. E.; DeAngelis, L. M.; Omuro, A.
Article Title:	Longitudinal cognitive assessment in patients with primary CNS lymphoma treated with induction chemotherapy followed by reduced-dose whole-brain radiotherapy or autologous stem cell transplantation
Abstract:	Introduction: The standard treatment for primary central nervous system lymphoma (PCNSL) involves induction methotrexate-based chemotherapy with or without consolidation whole brain radiotherapy (WBRT). As WBRT carries a substantial risk for cognitive impairment, alternative consolidation treatments have been used to reduce neurotoxicity, including reduced-dose WBRT (rdWBRT) or high-dose chemotherapy with autologous stem cell transplant (HDC-ASCT). In this study, we characterized cognitive functions in PCNSL patients achieving long-term remission following rdWBRT or HDC-ASCT. Methods: PCNSL patients completed cognitive evaluations at diagnosis, post-induction chemotherapy, and yearly up to 5 years following rdWBRT or HDC-ASCT. Quality of life (QoL), white matter (WM) disease, and cortical atrophy (CA) on MRI were assessed at similar intervals. Results: Performance was impaired on most cognitive tests at diagnosis. Linear mixed model analyses in each group showed statistically significant improvement from baseline up to year 3 in attention/executive functions, graphomotor speed, and memory; however, there was a decline in attention/executive functions and memory after year 3 in both groups. WM abnormalities increased over time in both groups, but more patients treated with rdWBRT developed CA and WM changes. There were no significant longitudinal group differences in cognitive performance or QoL. Conclusions: Results indicated improvement in cognitive function up to 3 years post-treatment, but a decline at later time points and an increase in brain structure abnormalities in both groups. The findings suggest that rdWBRT and HDC-ASCT may be associated with delayed neurotoxicity in progression-free patients and underscore the need for long-term follow-up to characterize cognitive dysfunction in PCNSL patients. © 2019, Springer Science+Business Media, LLC, part of Springer Nature.
Keywords:	adult; clinical article; aged; radiation dose; chemotherapy; primary central nervous system lymphoma; methotrexate; rituximab; nuclear magnetic resonance imaging; quality of life; radiotherapy; vincristine; autologous stem cell transplantation; procarbazine; remission; cognition; cognitive; primary cns lymphoma; motor performance; memory; attention; induction chemotherapy; autologous stem cell transplant; mental performance; whole brain radiotherapy; brain atrophy; executive function; human; male; female; article; cognitive function test; mental disease assessment
Journal Title:	Journal of Neuro-Oncology
Volume:	144
Issue:	3
ISSN:	0167-594X
Publisher:	Springer
Date Published:	2019-09-01
Start Page:	553
End Page:	562
Language:	English
DOI:	10.1007/s11060-019-03257-1
PUBMED:	31377920
PROVIDER:	scopus
PMCID:	PMC7392129
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85072717898&doi=10.1007%2fs11060-019-03257-1&partnerID=40&md5=a3c583977435f5c1fb58b64ca1f30627
Notes:	Source: Scopus

https://synapse.mskcc.org/synapse/works/has_related_data_chk/155303