BRCA2: Safeguarding the genome through homologous recombination Book Section
| Authors: | Christ, N.; Moynahan, M. E.; Jasin, M. |
| Editors: | Aguilera, A.; Rothstein, R. |
| Article/Chapter Title: | BRCA2: Safeguarding the genome through homologous recombination |
| Title Series: | Topics in Current Genetics |
| Abstract: | Germline mutations in the tumor suppressor gene BRCA2 predispose individuals to breast, ovarian, and other cancers. In recent years, the BRCA2 protein has been recognized to have an important function in homologous recombination, a key pathway in mammalian cells for repairing spontaneous and induced DNA lesions and, thus, for maintaining genomic integrity. Loss of BRCA2 leads to embryonic death in mice, but is compatible with cell survival in adult somatic cells and tumor proliferation. This review summarizes recent advances in our understanding of BRCA2 from several perspectives, especially with regard to its broad evolutionary conservation. © 2007 Springer-Verlag Berlin Heidelberg. |
| Book Title: | Molecular Genetics of Recombination |
| Volume: | 17 |
| ISBN: | 978-3-540-71020-2 |
| Publisher: | Springer Verlag |
| Publication Place: | Berlin, Germany |
| Date Published: | 2007-01-01 |
| Start Page: | 363 |
| End Page: | 380 |
| Language: | English |
| DOI: | 10.1007/4735_2007_0216 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Export Date: 17 November 2011" - "Source: Scopus" |
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