Single-cell transcriptomics identifies a distinct luminal progenitor cell type in distal prostate invagination tips Journal Article


Authors: Guo, W.; Li, L.; He, J.; Liu, Z.; Han, M.; Li, F.; Xia, X.; Zhang, X.; Zhu, Y.; Wei, Y.; Li, Y.; Aji, R.; Dai, H.; Wei, H.; Li, C.; Chen, Y.; Chen, L.; Gao, D.
Article Title: Single-cell transcriptomics identifies a distinct luminal progenitor cell type in distal prostate invagination tips
Abstract: The identification of prostate stem/progenitor cells and characterization of the prostate epithelial cell lineage hierarchy are critical for understanding prostate cancer initiation. Here, we characterized 35,129 cells from mouse prostates, and identified a unique luminal cell type (termed type C luminal cell (Luminal-C)) marked by Tacstd2, Ck4 and Psca expression. Luminal-C cells located at the distal prostate invagination tips (termed Dist-Luminal-C) exhibited greater capacity for organoid formation in vitro and prostate epithelial duct regeneration in vivo. Lineage tracing of Luminal-C cells indicated that Dist-Luminal-C cells reconstituted distal prostate luminal lineages through self-renewal and differentiation. Deletion of Pten in Dist-Luminal-C cells resulted in prostatic intraepithelial neoplasia. We further characterized 11,374 human prostate cells and confirmed the existence of h-Luminal-C cells. Our study provides insights into the prostate lineage hierarchy, identifies Dist-Luminal-C cells as the luminal progenitor cell population in invagination tips and suggests one of the potential cellular origins of prostate cancer. © 2020, The Author(s), under exclusive licence to Springer Nature America, Inc.
Journal Title: Nature Genetics
Volume: 52
Issue: 9
ISSN: 1061-4036
Publisher: Nature Publishing Group  
Date Published: 2020-09-01
Start Page: 908
End Page: 918
Language: English
DOI: 10.1038/s41588-020-0642-1
PUBMED: 32807988
PROVIDER: scopus
DOI/URL:
Notes: Article -- Export Date: 1 October 2020 -- Source: Scopus
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  1. Yu Chen
    94 Chen