Low CD38 identifies progenitor-like inflammation-associated luminal cells that can initiate human prostate cancer and predict poor outcome Journal Article

   

Authors:	Liu, X.; Grogan, T. R.; Hieronymus, H.; Hashimoto, T.; Mottahedeh, J.; Cheng, D.; Zhang, L.; Huang, K.; Stoyanova, T.; Park, J. W.; Shkhyan, R. O.; Nowroozizadeh, B.; Rettig, M. B.; Sawyers, C. L.; Elashoff, D.; Horvath, S.; Huang, J.; Witte, O. N.; Goldstein, A. S.
Article Title:	Low CD38 identifies progenitor-like inflammation-associated luminal cells that can initiate human prostate cancer and predict poor outcome
Abstract:	Inflammation is a risk factor for prostate cancer, but the mechanisms by which inflammation increases that risk are poorly understood. Here, we demonstrate that low expression of CD38 identifies a progenitor-like subset of luminal cells in the human prostate. CD38lo luminal cells are enriched in glands adjacent to inflammatory cells and exhibit epithelial nuclear factor κB (NF-κB) signaling. In response to oncogenic transformation, CD38lo luminal cells can initiate human prostate cancer in an in vivo tissue-regeneration assay. Finally, the CD38lo luminal phenotype and gene signature are associated with disease progression and poor outcome in prostate cancer. Our results suggest that prostate inflammation expands the pool of progenitor-like target cells susceptible to tumorigenesis. © 2016 The Author(s)
Keywords:	inflammation; prostate cancer; stem cells; cell of origin; transformation; progenitor; luminal; cd38
Journal Title:	Cell Reports
Volume:	17
Issue:	10
ISSN:	2211-1247
Publisher:	Cell Press
Date Published:	2016-12-06
Start Page:	2596
End Page:	2606
Language:	English
DOI:	10.1016/j.celrep.2016.11.010
PROVIDER:	scopus
PUBMED:	27926864
PMCID:	PMC5367888
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85002581864&doi=10.1016%2fj.celrep.2016.11.010&partnerID=40&md5=bcf9479f99869b871cb21e040c5fb662
Notes:	Article -- Export Date: 3 January 2017 -- Source: Scopus

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