Tumour-initiating stem-like cells in human prostate cancer exhibit increased NF-κB signalling Journal Article


Authors: Rajasekhar, V. K.; Studer, L.; Gerald, W.; Socci, N. D.; Scher, H. I.
Article Title: Tumour-initiating stem-like cells in human prostate cancer exhibit increased NF-κB signalling
Abstract: Androgen depletion is a key strategy for treating human prostate cancer, but the presence of hormone-independent cells escaping treatment remains a major therapeutic challenge. Here, we identify a minor subset of stem-like human prostate tumour-initiating cells (TICs) that do not express prostate cancer markers, such as androgen receptor or prostate specific antigen. These TICs possess stem cell characteristics and multipotency as demonstrated by in vitro sphere-formation and in vivo tumour-initiation, respectively. The cells represent an undifferentiated subtype of basal cells and can be purified from prostate tumours based on coexpression of the human pluripotent stem cell marker TRA-1-60 with CD151 and CD166. Such triple-marker-positive TICs recapitulate the original parent tumour heterogeneity in serial xeno-transplantations indicating a tumour cell hierarchy in human prostate cancer development. These TICs exhibit increased nuclear factor-κB activity. These findings are important in understanding the molecular basis of human prostate cancer. © 2011 Macmillan Publishers Limited. All rights reserved.
Journal Title: Nature Communications
Volume: 2
ISSN: 2041-1723
Publisher: Nature Publishing Group  
Date Published: 2011-01-18
Start Page: 162
Language: English
DOI: 10.1038/ncomms1159
PROVIDER: scopus
PMCID: PMC3105310
PUBMED: 21245843
DOI/URL:
Notes: --- - "Export Date: 4 March 2011" - "Source: Scopus"
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MSK Authors
  1. William L Gerald
    375 Gerald
  2. Lorenz Studer
    173 Studer
  3. Nicholas D Socci
    207 Socci
  4. Howard Scher
    1036 Scher