Human natural cytotoxic activity mediated by tumor necrosis factor: Regulation by interleukin-2 Journal Article

  


Authors: Lattime, E. C.; Stoppacciaro, A.; Khan, A.; Stutman, O.
Article Title: Human natural cytotoxic activity mediated by tumor necrosis factor: Regulation by interleukin-2
Abstract: Freshly obtained normal lymphoid cells kill certain tumor target cells in vitro. Using peripheral-blood lymphocytes (PBLs) and the human tumor target cell line BT-20, we have defined a tumor necrosis factor (TNF)-dependent, cell-mediated cytotoxic mechanism that is homologous to the murine natural cytotoxic (NC) cell activity. Human NC cell activity was detected in freshly isolated PBLs and was augmented by short in vitro pulses with recombinant human interleudin-2 but not with recombinant human alfa interferon. Monoclonal anti-TNF antibodies inhibited the killing of the target cells. The independence of interferon and the mediation of killing by TNF distinguish human NC cell activity from natural killer and lymphokine-activated killer cell activitoes. [J Natl Cancer Inst 1988;80:1035-1038]. © 1988 Oxford University Press.
Keywords: human cell; interferon; cells, cultured; interleukin 2; cytotoxicity; physiology; immunology; cell culture; natural killer cell; killer cells, natural; cytotoxicity, immunologic; lymphocyte; lymphocytes; normal human; interleukin-2; tumor necrosis factor; cell mediated cytotoxicity; lymphoid cell; interferons; human; priority journal; article; support, non-u.s. gov't; support, u.s. gov't, p.h.s.
Journal Title: JNCI: Journal of the National Cancer Institute
Volume: 80
Issue: 13
ISSN: 0027-8874
Publisher: Oxford University Press  
Date Published: 1988-09-07
Start Page: 1035
End Page: 1038
Language: English
DOI: 10.1093/jnci/80.13.1035
PUBMED: 2457708
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0023820806&doi=10.1093%2fjnci%2f80.13.1035&partnerID=40&md5=2b75db6f0ad260f64772ee119143a063
Notes: Article -- Export Date: 6 August 2020 -- Source: Scopus
Altmetric
What is Altmetric?
Citation Impact
What is Dimensions Citation Badge?
BMJ Impact Analytics
MSK Authors
  1. Osias Stutman
    45 Stutman
  2. Edmund C. Lattime
    18 Lattime
Related MSK Work