Augmentation of natural killer cytotoxicity by alpha or gamma natural and recombinant interferons and interferon inducers: Effect of monocytes Journal Article
| Authors: | Platsoucas, C. D.; Fernandes, G.; Good, R. A.; Gupta, S. |
| Article Title: | Augmentation of natural killer cytotoxicity by alpha or gamma natural and recombinant interferons and interferon inducers: Effect of monocytes |
| Abstract: | We investigated the effect of human peripheral blood monocytes on the augmentation of natural killer cytotoxicity by α or γ natural and recombinant interferons (IFN) and certain interferon inducers. We observed that: (1) in the majority of the donors examined (75%) human peripheral blood monocytes do not affect natural killer cytotoxicity, determined by a 4-hour chromium-51 release assay, against target cells from hemopoietic human tumor cell lines. (2) Monocytes are not required and do not affect the augmentation of natural killer cytotoxicity by Escherichia coli-derived IFN-γ, natural human IFN-γ, E. coli-derived IFN-α2 or natural human IFN-α. E. coli-derived IFN-γ and natural human IFN-γ have been reported to activate monocyte cytotoxicity determined in 72-hour assay. (3) Monocytes are not required for the augmentation of natural killer cytotoxicity against target cells from hemopoietic tumor cell lines by polyinosinic acid-polycytidylic acid or staphylococcal enterotoxin A. |
| Keywords: | human cell; drug efficacy; drug potentiation; alpha interferon; cells, cultured; gamma interferon; recombinant proteins; natural killer cell; killer cells, natural; polyinosinic polycytidylic acid; cytotoxicity, immunologic; interferon inducers; drug cytotoxicity; monocyte; monocytes; drug administration; lymphocytes; normal human; interferon type i; intoxication; drug comparison; immunity, natural; interferon type ii; interferon inducing agent; human; male; female; priority journal; support, non-u.s. gov't; support, u.s. gov't, p.h.s.; support, u.s. gov't, non-p.h.s.; preliminary communication; blood and hemopoietic system |
| Journal Title: | International Archives of Allergy and Applied Immunology |
| Volume: | 79 |
| Issue: | 1 |
| ISSN: | 0020-5915 |
| Publisher: | Karger |
| Date Published: | 1986-01-01 |
| Start Page: | 1 |
| End Page: | 7 |
| Language: | English |
| PUBMED: | 3079737 |
| PROVIDER: | scopus |
| DOI: | 10.1159/000233933 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 18 August 2021 -- Source: Scopus |
