Susceptibility to lysis by natural killer and natural cytotoxic cells is independent of the mitotic stage of the target cell cycle Journal Article

  

Authors:	Lattime, E. C.; Bykowsky, M. J.; Stutman, O.
Article Title:	Susceptibility to lysis by natural killer and natural cytotoxic cells is independent of the mitotic stage of the target cell cycle
Abstract:	Natural cell-mediated cytotoxicity (NCMC) against a number of target cells is mediated by at least two distinct effector populations, with natural killer (NK) and natural cytotoxic (NC) cells being the predominant in the murine system. The studies described in this report examine the role that the phase of the mitotic cycle of the target cell has on its susceptibility to lysis by NC and NK cells. We show that neither the kinectics nor the magnitude of NC cell lysis is altered when assayed using target cells which have been enriched for G1, S, or G2 + M stages of the cell cycle. Similarly, NK cell lysis by fresh or poly-IC augmented effector cells was not effected by target Cell Cycle. © 1986.
Keywords:	nonhuman; mouse; animal; mice; cell cycle; spleen; cell line; animal experiment; cytotoxicity; mice, inbred c57bl; lymphoma; natural killer cell; killer cells, natural; cytotoxicity, immunologic; in vitro; spleen cell; immunity, cellular; sarcoma, experimental; priority journal; support, non-u.s. gov't; support, u.s. gov't, p.h.s.
Journal Title:	Cellular Immunology
Volume:	100
Issue:	1
ISSN:	0008-8749
Publisher:	Elsevier Inc.
Date Published:	1986-06-01
Start Page:	79
End Page:	88
Language:	English
DOI:	10.1016/0008-8749(86)90008-0
PUBMED:	3742603
PROVIDER:	scopus
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-0022615328&doi=10.1016%2f0008-8749%2886%2990008-0&partnerID=40&md5=88190fa993dbb8258a0c84c54a4f4349
Notes:	Article -- Export Date: 18 August 2021 -- Source: Scopus; Acknowledgments: We thank Dr. R. G. Miller (Ontario Cancer Institute, Toronto, Canada) for the equations used to determine the sedimentation velocities and Mr. C. Mueller and Mr. G. Pecoraro for expert technical assistance.

https://synapse.mskcc.org/synapse/works/has_related_data_chk/185484