Effect of total parenteral nutrition on whole body protein kinetics in cachectic patients with benign or malignant disease Journal Article

  


Authors: Jeevanandam, M.; Legaspi, A.; Lowry, S. F.; Horowitz, G. D.; Brennan, M. F.
Article Title: Effect of total parenteral nutrition on whole body protein kinetics in cachectic patients with benign or malignant disease
Abstract: The metabolic effects of total parenteral nutrition on malnourished cancer and noncancer patients were investigated by determining whole-body protein metabolism before and during intravenous nutritional support. The results were compared to similar studies reported in normal subjects. Primed-continuous infusion of 15N glycine was used and the isotopic enrichments in urinary urea and ammonia were measured. The end product average values were used in the calculation of whole body protein turnover. After 10 days of nutritional support in cancer and noncancer patients whole body protein breakdown decreased by 50% (p = 0.01), and 59% (p = 0.001), whereas protein synthesis decreased by 21% (p = 0.005), and 33% (p = 0.025), respectively. Protein turnover did not change in noncancer patients but increased by 15% (p = 0.005) in cancer patients. The efficiency of utilization of the endogenous supply of amino acids for the breakdown of body proteins for synthetic purposes was 77% in this group of subjects. The utilization efficiency of the intravenously infused amino acids for synthesis of body protein was 39% in cancer and noncancer patients but 51% (p < 0.05) in normals. The data suggest that depleted patients synthesize proteins from intravenous amino acids less well than normals.
Keywords: clinical article; controlled study; protein metabolism; total parenteral nutrition; cachexia; intravenous drug administration; normal human; cancer; human; male; female
Journal Title: Journal of Parenteral and Enteral Nutrition
Volume: 12
Issue: 3
ISSN: 0148-6071
Publisher: Sage Publications  
Date Published: 1988-05-01
Start Page: 229
End Page: 236
Language: English
DOI: 10.1177/0148607188012003229
PUBMED: 3134558
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0023937975&doi=10.1177%2f0148607188012003229&partnerID=40&md5=bef62180d7de52a9866e46f443aa2e52
Notes: Article -- Export Date: 6 August 2020 -- Source: Scopus
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MSK Authors
  1. Murray F Brennan
    1059 Brennan
  2. Stephen F Lowry
    20 Lowry
  3. Malayappa Jeevanandam
    38 Jeevanandam
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