Effect of systemic hyperinsulinemia in cancer patients Journal Article


Authors: Heslin, M. J.; Newman, E.; Wolf, R. F.; Pisters, P. W. T.; Brennan, M. F.
Article Title: Effect of systemic hyperinsulinemia in cancer patients
Abstract: Data defining the isolated effect of insulin on whole body protein and glucose metabolism in cancer patients are limited. Ten normal volunteers (controls), age 55 ± 3 years (mean ± SEM); 8 cancer patients, age 61 ± 3 years, weight loss 2 ± 1% (CANWL); and 8 cancer patients, age 55 ± 2 years, weight loss 18 ± 2% (CAWL), were studied in the post-absorptive state. Whole body leucine kinetics were determined during a baseline and then a study period during which insulin was infused at 1.0 milliunits/kg/min to achieve a high physiological level of 71 ±6,83 ± 5, and 64 ± 5 microunits/ml in controls, CANWL, and CAWL, respectively. Whole body net balance equals protein synthesis minus protein breakdown. Glucose disposal (mg/kg/min) is the rate of D30 infusion at steady state. Glucose disposal of CANWL and CAWL during the study period was significantly (P < 0.05, analysis of variance) less than controls (3.91 ± 0.6 in CANWL, 3.66 ± 1.0 in CAWL, and 5.87 ± 0.6 mg/kg/min in controls), suggesting resistance to insulin with respect to carbohydrate metabolism. Hyperinsulinemia, under cuglyccmic and near basal amino acid conditions, significantly reversed the negative postabsorptive leucine net balance (P < 0.05, analysis of variance) by decreasing protein breakdown in controls as well as weight-stable and weight-losing cancer patients, suggesting that cancer patients are not resistant to the anti-catabolic effect of insulin with respect to whole body protein metabolism. © 1992, American Association for Cancer Research. All rights reserved.
Keywords: adult; clinical article; controlled study; human tissue; human cell; cancer patient; proteins; protein metabolism; lung neoplasms; body weight; gastrointestinal neoplasms; protein synthesis; insulin; glucose; insulin blood level; insulin resistance; cachexia; leucine; intravenous drug administration; catabolism; middle age; glucose metabolism; hyperinsulinemia; hyperinsulinism; human; male; female; priority journal; article; support, non-u.s. gov't; support, u.s. gov't, p.h.s.; insulin infusion
Journal Title: Cancer Research
Volume: 52
Issue: 14
ISSN: 0008-5472
Publisher: American Association for Cancer Research  
Date Published: 1992-07-15
Start Page: 3845
End Page: 3850
Language: English
PUBMED: 1617658
PROVIDER: scopus
DOI/URL:
Notes: Article -- Export Date: 30 July 2019 -- Source: Scopus
Citation Impact
MSK Authors
  1. Murray F Brennan
    1002 Brennan
  2. Martin J. Heslin
    30 Heslin
  3. Peter W. T. Pisters
    21 Pisters
  4. Elliot Newman
    19 Newman
  5. Ronald F. Wolf
    15 Wolf