Cerebellar dysfunction in patients with bronchogenic carcinoma: Immunological investigations Journal Article
| Authors: | Wessel, K.; Budde-Steffen, C.; Wiethölter, H.; Diener, H. C.; Dichgans, J. |
| Article Title: | Cerebellar dysfunction in patients with bronchogenic carcinoma: Immunological investigations |
| Abstract: | Sera from seven patients with bronchogenic carcinoma and cerebellar dysfunction were tested for anti-Purkinje cell antibodies (APCA) by indirect immunofluorescence and indirect immunoperoxidase reaction. Specific APCA as described in paraneoplastic cerebellar degeneration (PCD) were not detected in any of these patients or in control patients. The lack of APCA in patients with bronchogenic carcinoma and their presence in association with ovarian or breast cancer indicate that different pathogenetic mechanisms may play a role in PCD. © 1988 Springer-Verlag. |
| Keywords: | adult; clinical article; aged; purkinje cell; immunofluorescence; neoplasm metastasis; histochemistry; lung carcinoma; paraneoplastic syndrome; autoantibodies; antibody; middle age; cerebellar ataxia; paraneoplastic cerebellar degeneration; carcinoma, bronchogenic; bronchogenic carcinoma; immunoperoxidase staining; human; male; female; priority journal; anti-purkinje cell antibodies |
| Journal Title: | Journal of Neurology Neurosurgery and Psychiatry |
| Volume: | 235 |
| Issue: | 5 |
| ISSN: | 0022-3050 |
| Publisher: | BMJ Publishing Group Ltd. |
| Date Published: | 1988-05-01 |
| Start Page: | 297 |
| End Page: | 299 |
| Language: | English |
| DOI: | 10.1007/bf00314177 |
| PUBMED: | 3385446 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 6 August 2020 -- Source: Scopus |
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