Anti-Yo mediated paraneoplastic cerebellar degeneration in the context of breast cancer: A case report and literature review Journal Article
| Authors: | Key, R. G.; Root, J. C. |
| Article Title: | Anti-Yo mediated paraneoplastic cerebellar degeneration in the context of breast cancer: A case report and literature review |
| Abstract: | Background Paraneoplastic syndromes are of interest to psycho-oncologists because they may be misdiagnosed initially as primary psychiatric disorders and can have profound neuropsychiatric and psychosocial sequelae. Paraneoplastic cerebellar degeneration (PCD) is a paraneoplastic syndrome which destroys Purkinje cells of the cerebellum and causes trunk and limb ataxia, dysarthria, diplopia, and vertigo, which often precede the diagnosis of cancer. Anti-Yo PCD is a devastating syndrome that significantly worsens prognosis in terms of functional ability and survival. Methods We present the case of a woman with progressive cerebellar deficits, which were misdiagnosed for several months before breast cancer and anti-Yo antibodies were discovered. Results PCD may be misdiagnosed as a primary psychiatric disorder. Results of neuropsychological assessment in this case found subtle attentional dysfunction but relatively preserved cognitive functioning in other domains. Discussion The literature relating to PCD and psychiatric manifestations of cerebellar disease are reviewed. The limitations of our current understanding of non-motor cerebellar function are highlighted, asserting the need for further study in this area. Copyright © 2013 John Wiley & Sons, Ltd. Copyright © 2013 John Wiley & Sons, Ltd. |
| Keywords: | immunohistochemistry; adult; antibiotic agent; antibiotic therapy; unclassified drug; case report; drug withdrawal; side effect; treatment duration; paclitaxel; nuclear magnetic resonance imaging; breast cancer; mastectomy; olanzapine; bedtime dosage; maintenance therapy; weight reduction; cyclophosphamide; dexamethasone; immunoglobulin; dissection; oncology; axillary lymph node; dysphagia; depression; length of stay; lumbar puncture; breast tumor; neuropsychological test; adjustment disorder; distress syndrome; nausea and vomiting; epirubicin; consultation; anxiety; headache; leukocyte count; trastuzumab; diplopia; irritability; clonazepam; sertraline; ataxia; antibody; cerebellum atrophy; rehabilitation care; paraneoplastic neuropathy; neck pain; cerebellar degeneration; mental instability; dysarthria; guillain barre syndrome; antibody blood level; nonverbal communication; crying; dysmetria; riluzole; anti-yo; paraneoplasic; yo antibody |
| Journal Title: | Psycho-Oncology |
| Volume: | 22 |
| Issue: | 9 |
| ISSN: | 1057-9249 |
| Publisher: | John Wiley & Sons |
| Date Published: | 2013-09-01 |
| Start Page: | 2152 |
| End Page: | 2155 |
| Language: | English |
| DOI: | 10.1002/pon.3270 |
| PROVIDER: | scopus |
| PUBMED: | 23585287 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 1 October 2013" - "CODEN: POJCE" - "Source: Scopus" |
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