Immunological characterization of a neuronal antibody (anti-Tr) associated with paraneoplastic cerebellar degeneration and Hodgkin's disease Journal Article
| Authors: | Graus, F.; Dalmau, J.; Valldeoriola, F.; Ferrer, I.; Reñé, R.; Marin, C.; Vecht, Ch J.; Arbizu, T.; Targa, C.; Moll, J. W. B. |
| Article Title: | Immunological characterization of a neuronal antibody (anti-Tr) associated with paraneoplastic cerebellar degeneration and Hodgkin's disease |
| Abstract: | We studied an autoantibody (called anti-Tr), found in the serum and CSF of five patients with paraneoplastic cerebellar degeneration (PCD) and Hodgkin's disease (HD). Anti-Tr antibodies labelled the cytoplasm of Purkinje cells of human and rat cerebellum. The molecular layer of rat cerebellum showed a characteristic dotted pattern suggestive of immunoreactivity of dendritic spines of Purkinje cells. Patients with cerebellar disorders without HD (159) or HD without PCD (30) did not harbor anti-Tr antibodies. Immunoblots of human Purkinje cells or rat and mouse cerebellum were negative. Anti-Tr antibodies, as defined in this study, appear specific for HD-associated PCD. The immunohistochemical pattern described in the rat cerebellum coupled with the absence of reactivity in the immunoblot may be used to identify anti-Tr antibodies. |
| Keywords: | immunohistochemistry; adolescent; adult; clinical article; aged; animals; mice; neurons; mice, inbred balb c; hodgkin disease; tissue distribution; immunoblotting; rats; antibodies; autoantibody; rats, wistar; nerve cell; autoantibodies; nerve degeneration; cerebellar diseases; paraneoplastic syndromes; hodgkin's disease; paraneoplastic; humans; human; male; female; priority journal; article; brain degeneration; cerebellar disease |
| Journal Title: | Journal of Neuroimmunology |
| Volume: | 74 |
| Issue: | 1-2 |
| ISSN: | 0165-5728 |
| Publisher: | Elsevier Inc. |
| Date Published: | 1997-04-01 |
| Start Page: | 55 |
| End Page: | 61 |
| Language: | English |
| DOI: | 10.1016/s0165-5728(96)00205-6 |
| PUBMED: | 9119979 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 17 March 2017 -- Source: Scopus |
