Multiple Mu opiate receptors Journal Article

  


Author: Pasternak, G. W.
Article Title: Multiple Mu opiate receptors
Abstract: Soon after the identification of the enkephalins, discrete receptors for [Met5]- and [leu5]enkephalin (delta) and for morphine (mu) were proposed. Much evidence supported the presence of these two receptor classes. Recent evidence now suggests two subtypes of mu receptors, mu1 and mu2. In addition to differences in their binding selectivity, regional distribution, phylogeny, and development, mu1 and mu2 receptors are responsible for different opiate actions. For example, mu1 receptors mediate supraspinal analgesia, whereas mu2 receptors are involved in respiratory depression and gastrointestinal transit.
Keywords: review; nonhuman; animal cell; opiate; animal experiment; drug receptor binding; drug antagonism; rat; morphine; respiration depression; analgesia; mu opiate receptor; naloxone; n allylnormetazocine; levallorphan; ketazocine; diprenorphine; enkephalin derivative; dynorphin derivative; endorphin derivative
Journal Title: ISI Atlas of Science: Pharmacology
Volume: 2
Issue: 2
ISSN: 0890-9083
Publisher: Thomson Reuters  
Date Published: 1988-01-01
Start Page: 148
End Page: 154
Language: English
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0023939895&partnerID=40&md5=fb1c4543d3c8c37465b50e796dfcfc2e
Notes: Article -- Source: Scopus