Minireview: Multiple mu opiate receptors Journal Article
| Authors: | Pasternak, G. W.; Wood, P. J. |
| Article Title: | Minireview: Multiple mu opiate receptors |
| Abstract: | In addition to morphine-selective mu2 and enkephalin-preferring delta sites, recent evidence supports the presence within the central nervous system of a common site with very high affinity for both enkephalins and opiates termed tht mu1 site. This concept of a common, very high affinity site for multiple neurotransmitters is a unique concept in neuropharmacology, differing from classical transmitter systems which possess multiple receptor classes for a single transmitter. This review will address both the biochemical and pharmacological evidence supporting the existence of this site. © 1986. |
| Keywords: | nonhuman; animal cell; animal; central nervous system; drug receptor binding; tissue distribution; brain; rat; aging; radioisotope; morphine; substance-related disorders; respiration; analgesia; receptors, opioid, mu; autoradiography; pharmacokinetics; naloxone; opiate receptor; phylogeny; nervous system; drug interaction; survey; binding, competitive; synaptosome; enkephalin; ethylketazocine; neurotransmitters; levallorphan; ketazocine; receptors, opioid; naloxazone; priority journal; dihydromorphine; endorphins; enkephalin, leucine-2-alanine; enkephalins; ethylmaleimide; enkephalin, leucine; enkephalin[2 alanine 5 leucine]; metkephamid; enkephalin[2 alanine 5 leucine] h 3; dihydromorphine h 3; metenkephalin[alanine] |
| Journal Title: | Life Sciences |
| Volume: | 38 |
| Issue: | 21 |
| ISSN: | 0024-3205 |
| Publisher: | Elsevier Inc. |
| Date Published: | 1986-05-26 |
| Start Page: | 1889 |
| End Page: | 1898 |
| Language: | English |
| DOI: | 10.1016/0024-3205(86)90217-1 |
| PUBMED: | 2872563 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 18 August 2021 -- Source: Scopus |
