Pinocchio cells: Morphologically atypical immunologically heterogeneous lymphocytes induced by treatment with interleukin 2 Journal Article
| Authors: | Paciucci, P. A.; Garin Chesa, P.; Fierro, M. T.; Gordon, R.; Konefal, R. G.; Glidewell, O.; Holland, J. F. |
| Article Title: | Pinocchio cells: Morphologically atypical immunologically heterogeneous lymphocytes induced by treatment with interleukin 2 |
| Abstract: | We describe a novel cell type, the Pinocchio cell, that appears in the peripheral blood of all patients receiving treatment with interleukin 2, up to 20000 cells/μl. This cell is characterized by a prominent and granular proboscis with which it attaches to tumor cells and mediates tumor cell lysis. Pinocchio cells are immunologically heterogeneous and express antigens of both T and NK cells; Pinocchio cells are adherent in culture and are more cytolytic than non-adherent cells against NK-sensitive and resistant tumor cells. Incubation of normal whole human blood for 1 h induces Pinocchio morphology of mononuclear white blood cells. © 1988. |
| Keywords: | human cell; neoplasms; t-lymphocytes; cytology; interleukin 2; immunotherapy; cell movement; killer cells, natural; cytotoxicity, immunologic; cell adhesion; lymphocyte; lymphocytes; ultrastructure; interleukin-2; in vitro; antigens, differentiation; cancer; human; priority journal; support, non-u.s. gov't; support, u.s. gov't, p.h.s.; pinocchio cells; pinocchio cell |
| Journal Title: | Immunology Letters |
| Volume: | 19 |
| Issue: | 4 |
| ISSN: | 0165-2478 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 1988-12-01 |
| Start Page: | 313 |
| End Page: | 320 |
| Language: | English |
| DOI: | 10.1016/0165-2478(88)90161-7 |
| PUBMED: | 3266613 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Source: Scopus |
